Induction of Diabetes Mellitus Using Alloxan in Sprague Dawley Rats
Jong-Min Kim
Abstract:Purpose: The use of rodent models for diabetes, particularly with pancreatic islet transplantation, has been prevalent in various preclinical trials. The purpose of this study is to establish a diabetes mellitus (DM) model in Sprague Dawley (SD) rats using alloxan evaluated by assessing alloxan dosage, the induction rate of diabetes, and glucose stability through insulin treatment.
Methods: Over the course of 13 experimental rounds, diabetes was induced in 86 SD rats using alloxan at concentrations … Show more
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