Induction of differentiation of cultured human promyelocytic leukemia cells by retinoids

Honma, Yoshio; Takenaga, Keizo; Kasukabe, Takashi; Hozumi, Motoo

doi:10.1016/0006-291x(80)90813-x

Cited by 117 publications

(45 citation statements)

References 5 publications

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“…Much attention has been focused recently on the antitumor activity of such vitamins as retinoic acid (29,30) and ascorbic acid (31,32). However, to our knowledge, it has not been reported before that vitamin D derivatives show antitumor activity in vivo.…”

Section: Discussionmentioning

confidence: 99%

1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

Honma¹,

Hozumi²,

Abe³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

230

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Syngeneic SL mice inoculated with murine myeloid leukemia cells (Ml) all died ofleukemia within 30 days. Treatment three times a week with 12.5-50 pmol per mouse of either la,25-dihydroxyvitamin D3 [la,25(OH) It is of great interest that some tumor cell lines also possess similar cytosol receptors to which la,25(OH)2D3 binds specifically (4-6). However, the biological function of la,25(OH)2D3 in tumor cells was not known until quite recently. In 1981, Colston et aL (7) (17,18), the most potent known stimulators in Ml cells, do not induce differentiation of HL-60 cells (13,19).It is known that syngeneic SL mice inoculated with MI cells all die of leukemia (20,21). The marked in vitro effects of la,25(OH)2D3 on cell growth and differentiation (8, 10, 19) led us to examine whether in vivo administration of la,25(OH)2D3 to tumor-bearing mice would decrease their leukemogenicity.In this report, we demonstrate that treatment with either la,25(OH)2D3 or la(OH)D3 considerably prolongs survival times of mice inoculated with Ml cells. MATERIALS AND METHODSAnimals. Inbred SL strain mice were maintained as reported previously (20,21). Six-to eight-week old female mice were used for the experiments. Six-week-old female athymic nude mice with a BALB/c genetic background were supplied by CLEA Japan (Tokyo). They were housed under specific pathogen-free conditions by using Clean Racks (Sanki Kogyo, Tokyo).Inoculation with MI Cells. Ml cells, clone S1 (a clone sensitive to dexamethasone), were maintained as reported (22) 3, 6, 12, 24, or 48 hr later and their blood was collected. The blood plasma Abbreviations: Ml, a murine myeloid leukemia cell line; HL-60, a human myeloid leukemia cell line; la,25(OH)2D3, la,25-dihydroxyvitamin D3; la(OH)D3, la-hydroxyvitamin D3; 25(OH)D3, 25-hydroxyvitamin D3; 24R,25(OH)2D3, 24R,25-dihydroxyvitamin D3.¶ To whom reprint requests should be addressed. 201The publication costs ofthis article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.

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Section: Discussionmentioning

confidence: 99%

1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

Honma¹,

Hozumi²,

Abe³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

230

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“…19,20 The NBT-reducing activity induced by MJ was more than additively enhanced by the addition of ATRA (Figure 4a). Morphological changes in granulocytes were also enhanced by MJ plus ATRA (data not shown).…”

Section: Effects Of Other Inducers On the Mj-induced Differentiation mentioning

confidence: 99%

Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones

et al. 2004

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Some regulators of plant growth and differentiation have been shown to induce the differentiation of several human myeloid leukemia cells, and might be effective as differentiation inducers to control acute myelogenous leukemia cells. In this study, the growth-inhibiting and differentiation-inducing effects of jasmonates on human myeloid leukemia cells were examined. Several myeloid leukemia cells were cultured with methyl jasmonate (MJ) and its derivatives. Cell differentiation was determined by nitroblue tetrazolium-reducing activity, morphological changes, a-naphthyl acetate esterase activity and expression of differentiation-associated surface antigens. MJ induced both monocytic and granulocytic differentiation of HL-60 cells. MJ activated mitogen-activated protein kinase (MAPK) in the cells before causing myelomonocytic differentiation. MAPK activation was necessary for MJ-induced differentiation, since PD98059, an inhibitor of MAPK kinase, suppressed the differentiation induced by MJ. MJ also induced the differentiation of other human leukemia cell lines. Introduction of a double bond at the 4,5-position greatly enhanced the differentiationinducing activity of MJ. MJ and its derivatives potently induce the differentiation of some myelomonocytic leukemia cells. One novel derivative is a particularly promising therapeutic agent for the treatment of leukemia.

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“…From each sample, 1 mg of RNA was reverse-transcribed using MuLV reverse-transcriptase (Takara Biomedicals, Shiga, Japan), 1 mM deoxyribonucleoside triphosphate (dNTP), and 0.5 mg/ml of oligo (dT [12][13][14][15][16][17][18] ) (Bioneer, Seoul). Then PCR analyses were performed on the aliquots of the cDNA preparations to detect p21, c-myc and b-actin gene expression using a thermal cycler (Perkin Elmer Cetus, Foster City, CA, U.S.A.).…”

Section: Saucernetin-8 Isolated Frommentioning

confidence: 99%

“…13,14) The HL-60 cell line, derived from a patient with acute promyelocytic leukemia, provides a useful model system for studying the cellular and molecular events involved in the differentiation process. 15) Certain compounds, known to be efficacious cancer preventative agents, such as interferon, 16) retinoids, 17) 1a,25-(OH) 2 D 3 18) are potent inducers of HL-60 cell differentiation, and appear to be clinically effective against myeloproliferative disorders. Thus, the strategy that manipulates HL-60 cell differentiation has been used as a valid model to discover potential cancer chemopreventive agents in preclinical evaluation.…”

mentioning

confidence: 99%

Saucernetin-8 Isolated from Saururus chinensis Induced the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells

Seo

Yoo

Park

et al. 2004

Biological & Pharmaceutical Bulletin

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The underground or the aerial part of Saururus chinensis (LOUR.) BAILL (Saururaceae) has been used as a folk medicine to treat edema, jaundice, and gonorrhea in Korea.1) Several constituents such as lignans, neolignans, 2) acyclic diterpenes, 3) aristolactams, 4) and particularly manassantin A and B 5) classified as dineolignans have been isolated from the genus Saururus. In addition, the constituent sauchinone and its stereoisomers, a phenylpropanoid (sarisan), lignans (galbacin and saucernetin), 6) diarylbutane lignans, 7) tetrahydrofuran-type sesquilignans, 8) and furanoditerpenes 9) were isolated from S. chinensis. It was reported that sauchinone, a lignan from S. chinensis, attenuated CCl 4 -induced toxicity in primary cultures of rat hepatocytes.10) Further, we previously demonstrated that the methanol extract and its active constituents, saucernetin-7 and saucernetin-8, isolated from S. chinensis inhibited the LPS-induced iNOS and COX-2 expression by blocking NF-kB activation. 11,12) Tumors are diverse and heterogeneous, but all share the ability to proliferate beyond the constraints limiting growth in normal tissue. Deregulated cell proliferation together with suppressed apoptosis and differentiation constitute the minimal commom platform upon which all neoplastic evolution occurs. Based on the understanding of tumor biology in respect to the kinetics of cell populations, two new strategies, induction of differentiation and apoptosis, have recently emerged in the fields of cancer chemoprevention and chemotherapy. Differentiation from malignant or premalignant cells into more mature or normal-like cells as well as apoptosis in multistep carcinogenesis are theoretically amenable to preventive cancer intervention. Thus, compounds capable of inducing differentiation are considered as candidate agents for the prevention and/or treatment of cancer. 13,14) The HL-60 cell line, derived from a patient with acute promyelocytic leukemia, provides a useful model system for studying the cellular and molecular events involved in the differentiation process.15) Certain compounds, known to be efficacious cancer preventative agents, such as interferon, 16) retinoids, 17) 1a,25-(OH) 2 D 3 18) are potent inducers of HL-60 cell differentiation, and appear to be clinically effective against myeloproliferative disorders. Thus, the strategy that manipulates HL-60 cell differentiation has been used as a valid model to discover potential cancer chemopreventive agents in preclinical evaluation. Thus, as a part of our screening program to evaluate the chemopreventive potential effect of natural compounds, we have investigated the effect of saucernetin-8, which was isolated from the underground parts of Saururus chinensis, on HL-60 growth and induction of differentiation. Various biochemical and morphological examinations performed in the present study indicated that saucernetin-8 contains the activity to induce HL-60 cell differentiation. Furthermore, we demonstrated that the expression of p21 CIP1 cyclin dependent kinase inhibito...

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Induction of differentiation of cultured human promyelocytic leukemia cells by retinoids

Cited by 117 publications

References 5 publications

1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.

Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones

Saucernetin-8 Isolated from Saururus chinensis Induced the Differentiation of Human Acute Promyelocytic Leukemia HL-60 Cells

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