Induction of DNA fragmentation, chromosome aberrations and micronuclei by cisplatin in rat bone-marrow cells: Protective effect of recombinant human erythropoietin

Rjiba-Touati, Karima; Ayed-Boussema, Imen; Skhiri, H.; Belarbia, A.; Zellema, Dorsaf; Achour, A.; Bacha, Hassen

doi:10.1016/j.mrgentox.2012.05.011

Cited by 21 publications

(8 citation statements)

References 43 publications

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“…Experiments to date, have been aimed at uncovering an anti-apoptotic effect in stem cell precursors. Future work will be directed toward the study of the hypothesis that like EPO, HBSP may prevent or reverse DNA damage (Rjiba-Touati et al, 2012 and investigating the effects of other molecules that stimulate HIF-1alpha in bone marrow failure (Forristal et al, 2013).…”

Section: Experimental Design and Methodsmentioning

confidence: 99%

Novel Tissue Protective Agents for the Treatment of Acute Radiation-induced Bone Marrow Failure

Hand¹

2012

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Section: Experimental Design and Methodsmentioning

confidence: 99%

Novel Tissue Protective Agents for the Treatment of Acute Radiation-induced Bone Marrow Failure

Hand¹

2012

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“…Cytogenetic studies showed that DB and DBE treatment were highly effective in decreasing both simple and complex chromosomal aberrations. Furthermore, DB and DBE could sooth the damages to erythropoiesis, minimize radiation induced genomic instability of bone marrow cells, enhance recovery and improve survival from severe radiationinduced myelosuppression like recombinant human granulocyte colony-stimulating factor (GCSF), by decreasing the frequency of micronuclei [38], potentially providing a protection for living body exposed with ionizing irradiation. Radiation-induced chromosomal aberrations in mouse bone marrow have been shown in Figure 4.…”

Section: Radio-protective Effect On Bone Marrowmentioning

confidence: 99%

Meta-analysis of dragon’s blood resin extract as radio-protective agent

Mahmood¹,

Fatima²,

Zulfaqar³

et al. 2017

JCLM

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“…CDDP-treated mice showed high proportion of TUNEL-positive cells. This may be due to the direct cytotoxicity or extensive induction of DNA damage that leads to cell death (5). Treatment with the vanadium compound diminished this apoptotic cell death and conferred cytoprotection to the host.…”

Section: Restoration Of Gsh and Gssg Levelsmentioning

confidence: 99%

“…These toxic effects get resulted into sub-therapeutic dose delivery and/or discontinuation of chemotherapy, which ultimately compromise treatment outcome including disease control and survival in patients with curable malignancies (4). Beside this, the clastogenic potential of CDDP has become an alarming factor due to its deleterious effect on the genome of normal host cells (5). In patients treated long-term with CDDP, genetic damage can be observed during chemotherapy and/ or many years later in terms of infertility, teratogenicity and even through development of secondary malignancies (6,7).…”

Section: Introductionmentioning

confidence: 99%

Prevention of myelosuppression and genotoxicity induced by cisplatin in murine bone marrow cells: effect of an organovanadium compound vanadium(III)-l-cysteine

et al. 2015

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Cisplatin (CDDP) is one of the first-line anticancer drugs indicated for use against various form of human malignancies; but, the therapeutic outcome of CDDP chemotherapy is limited due to the development of myelosuppression and genotoxicity which may lead to secondary cancer. Induction of oxidative stress in normal host cells is thought to be responsible for these adverse effects. Therefore, in search of a potential chemoprotectant, an oraganovanadium compound, viz., vanadium(III)-l-cysteine (VC-III) was evaluated against CDDP-induced clastogenicity and cytotoxicity in bone marrow cells of Swiss albino mice. CDDP was administered intraperitoneally (5mg/kg body weight [b.w.]) and VC-III was given by oral gavage (1mg/kg b.w.) in concomitant and pretreatment schedule. The results showed that VC-III administration significantly (P < 0.001) enhanced cell proliferation and inhibited apoptosis in the bone marrow niche indicating recovery of CDDP-induced myelosuppression. VC-III also significantly (P < 0.001) decreased the percentage of chromosomal aberrations, the frequency of micronuclei formation and the extent of DNA damage. The observed antigenotoxic and cytoprotective effect of VC-III was attributed to its attenuation of free radicals status and restoration of oxidised and reduced glutathione levels. These results suggest that VC-III is a potential candidate for future development as a chemoprotective agent against chemotherapy-associated primary and secondary complications.

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Induction of DNA fragmentation, chromosome aberrations and micronuclei by cisplatin in rat bone-marrow cells: Protective effect of recombinant human erythropoietin

Cited by 21 publications

References 43 publications

Novel Tissue Protective Agents for the Treatment of Acute Radiation-induced Bone Marrow Failure

Novel Tissue Protective Agents for the Treatment of Acute Radiation-induced Bone Marrow Failure

Meta-analysis of dragon’s blood resin extract as radio-protective agent

Prevention of myelosuppression and genotoxicity induced by cisplatin in murine bone marrow cells: effect of an organovanadium compound vanadium(III)-l-cysteine

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