Induction of eosinophil-infiltrating drug photoallergy in mice

Nishio, Daisuke; Nakashima, Daiki; Mori, Tomoko; Kabashima, Kenji; Tokura, Y.

doi:10.1016/j.jdermsci.2009.02.011

Cited by 3 publications

(14 citation statements)

References 26 publications

(47 reference statements)

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“…Various drugs have been reported to induce photosensitivity, including quinolones as represented by FQs [6,47,48], afloqualone (AQ) [13,49], NSAIDs [20,22,35,50] and others. TaBle 1 summarizes the top 25 drugs with high incidence of photosensitivity reported in the period of 1980-2006 in the Japanese literature (total of 718 cases).…”

Section: Causative Drugsmentioning

confidence: 99%

“…We have taken several different approaches to establish mouse models of drug photoallergy with the use of AQ [13,49] and FQs [47]. Drug photoallergy is successfully induced and elicited by systemic administration of a drug and subsequent UVA irradiation of the skin [13,47], which is mimicry of clinical drug photoallergy.…”

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

“…In another system, photoallergy is induced by sensitization and elicitation with subcutaneous injections of epidermal cells that are photomodified in vitro with a drug under UVA exposure [13]. The involvement of T cells in drug photoallergy has been clearly demonstrated by mouse models of photoallergy to FQ and AQ [47,49]. Drug photoallergy is mediated by CD4 + T cells [47,49], and epidermal LCs are photomodified with a given drug and capable of inducing the proliferation of primed CD4 + T cells [47].…”

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

“…The involvement of T cells in drug photoallergy has been clearly demonstrated by mouse models of photoallergy to FQ and AQ [47,49]. Drug photoallergy is mediated by CD4 + T cells [47,49], and epidermal LCs are photomodified with a given drug and capable of inducing the proliferation of primed CD4 + T cells [47]. CD8 + T cells may be required for the full blown sensitivity [35,49].…”

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

“…We have also established a murine model of eosinophilinfiltrating drug photoallergy by administration of AQ in combination with UVA irradiation [49]. Repeated sensitization (>ten-times) with AQ plus UVA successfully induces eosinophil infiltration upon challenge with subcutaneous AQ plus UVA irradiation in AKR/J mice.…”

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

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Photoallergy

Tokura¹

2009

Expert Review of Dermatology

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There are two mechanisms underlying photosensitivity to exogenous agents: phototoxicity and photoallergy. While the phototoxic reaction is mediated mainly by free radicals, the photoallergic reaction is induced and elicited by immunological consequences. Photosensitive chemicals have a haptenic moiety, and two hypotheses have been put forward to explain the formation of photoallergens: prohaptens and photohaptens. Photohaptens need to coexist with a protein and, upon UV irradiation, a covalent bond is formed. The vast majority of clinically photoallergic chemicals are photohaptens rather than prohaptens. In a clinical photopatch test, a causative chemical is applied to the skin and UVA is irradiated to the site. This method tests the photohaptenic property. Clinically, photocontact dermatitis and drug photosensitivity are the two major disorders caused by topical and systemic exogenous photosensitizers, respectively. In photocontact dermatitis, halogenated salicylanilide and the related compounds musk ambrette, 6-methylcoumarin and benzophenone-3 (oxybenzone), were causative and, recently, topical NSAIDs have been another leading cause. In drug photosensitivity there have been many photosensitive drugs, including quinolones, piroxicam, afloqualone, griseofluvin, tegafur and tilisolol. The underlying mechanisms involve topically applied or orally administered chemicals diffusing from the skin surface or blood to the epidermis, and epidermal cells are photoderivatized with a given chemical upon UVA irradiation. Antigen-presenting dendritic cells are photomodified with the chemical upon exposure of the skin to UVA and become photohapten-bearing, T-cell stimulatory cells.

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Section: Causative Drugsmentioning

confidence: 99%

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

Section: Mouse Model Of Drug Photoallergymentioning

confidence: 99%

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Photoallergy

Tokura¹

2009

Expert Review of Dermatology

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Drug photoallergy

Tokura

2018

J Cutaneous Imm & Allergy

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Drugs are one of the representative exogenous agents that cause photosensitive dermatitis. Both phototoxic and photoallergic mechanisms exist in photosensitivity to exogenous agents. While the phototoxic reaction is mediated mainly by reactive oxygen species, the photoallergic reaction is induced and elicited by immunological consequences. Two hypotheses have been put forward to explain the formation of photoallergen: prohapten and photohapten. The vast majority of clinically photoallergic drugs are photohapten rather than prohapten. Clinically, photocontact dermatitis and drug photosensitivity are the two major disorders caused by topical and systemic exogenous photosensitizers, respectively. The main cause of photocontact dermatitis is nonsteroidal anti‐inflammatory drugs. In drug photosensitivity, various causative agents have been reported and are recently represented by hydrochlorothiazide, quinolones, piroxicam, and flutamide. Orally administered drugs diffuse from the blood to the epidermis, and keratinocytes are photoderivatized with a given drug upon ultraviolet (UV) A irradiation, leading to photoantigen formation and cytokine production. In parallel, dendritic cells become photohapten‐bearing, T‐cell–sensitizing cells. Considering the mechanisms of photoallergy to chemicals, several in vitro assessments have been proposed to detect the photoallergenicity. Finally, a recent observation with newly marketed drugs has demonstrated that drugs may function as immunomodulators and induce photosensitivity as typically seen in anti‐CCR4 antibody.

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Drugs and Physical Agents

2013

Practical Skin Pathology

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Induction of eosinophil-infiltrating drug photoallergy in mice

Cited by 3 publications

References 26 publications

Photoallergy

Photoallergy

Drug photoallergy

Drugs and Physical Agents

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