2009
DOI: 10.1016/j.cellimm.2009.03.004
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Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors

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Cited by 84 publications
(56 citation statements)
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“…15,16 We previously reported that the combined administration of rapamycin and IL-2 expanded donor Tregs and reduced acute GVHD in a murine model. 17 However, these agents could work nonspecifically and might adversely affect other cell populations.…”
Section: Cd25mentioning
confidence: 99%
“…15,16 We previously reported that the combined administration of rapamycin and IL-2 expanded donor Tregs and reduced acute GVHD in a murine model. 17 However, these agents could work nonspecifically and might adversely affect other cell populations.…”
Section: Cd25mentioning
confidence: 99%
“…Intranasal Insulin Trial I [26] 3. Intranasal Insulin for Prevention of T1D trial [27] These studies using oral or intranasal insulin therapy in humans have had either no or limited clinical benefit in human T1D [28,29]. Subsequent subgroup analysis of data from the DPT-1 trial supported the hypothesis that patients with high insulin-specific antibody titres who received oral insulin had a delay in progression to T1D [24].…”
Section: Abbreviationsmentioning
confidence: 86%
“…Increased Treg suppressive function (in combination and alone) EX-527 increased acetylation of K31, K262 and K267, and increased the stability and levels of the transcription factor [91,96] Foxp3/Tregs HDAC1-3 inhibitor MS-275 Ambiguous effects [98][99][100] RORγt/Th17 HDAC1-3 inhibitor MS-275 Enhanced Th17 differentiation in mouse splenocytes [106] RORγt/Th17 Pan HDACi givinostat Downregulated the IL-6 receptor on T cells that reduced their ability to differentiate into Th17 cells, but instead skewed differentiation toward the Treg phenotype [107] Foxp3 and RORγt Pan HDACi TSA Increased Foxp3 and decreased RoRγt levels in an ovalbumin challenge asthma mouse model [38] HDAC: Histone deacetylase; HDACi: Histone deacetylase inhibitor; PBMC: Peripheral blood mononuclear cell; TSA: Trichostatin A.…”
Section: Macrophages: Selective Regulation Of the Nf-κb Transcriptionmentioning
confidence: 99%
“…Furthermore, Sirt1 inhibitor EX-527 was used in a study where acetylation sites were identified on Foxp3 (K31, K262 and K267), and increased acetylation of these lysines as well as the stability and levels of the transcription factor [91]. HDAC1-3 inhibitor MS-275 increased Foxp3 expression in T cells isolated from human blood [98]. In other studies focusing on cancer models, however, downregulated Foxp3 expression by Tregs has also been reported upon MS-275 treatment [99,100].…”
Section: Tregs: Regulation Of the Foxp3 Transcription Factor Acetylatmentioning
confidence: 99%
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