Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension

Wang, Qingting; Chai, Limin; Zhang, Qianqian; Wang, Jian; Liu, Jin; Chen, Huan; Wang, Yan; Chen, Yuqian; Shen, Nirui; Xie, Xinming; Li, Manxiang

doi:10.1016/j.yjmcc.2022.06.012

Cited by 9 publications

(4 citation statements)

References 50 publications

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“…This study established the protective effects of DHA in PH through the ELAVL2/miR-503/PI3K/AKT axis and provided a potential therapeutic target for the treatment of PH. Wang et al found that elevated miR-27b-3p induced glioma-associated oncogene homolog 1 (GLI1) expression in endothelin-1 (ET-1)-treated PASMCs [149]. Their study showed elevated levels of GLI1 in ET-1-treated PASMCs, whereas knockdown of GLI1 decreased PASMC proliferation and migration mediated by ET-1.…”

Section: Pulmonary Hypertensionmentioning

confidence: 99%

Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases

Kawaguchi

Moukette

Hayasaka

et al. 2023

JCDD

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Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and cardiovascular diseases (CVDs), which are a major cause of morbidity and mortality. With advances in RNA sequencing technology, the focus of recent research has transitioned from studies of specific candidates to whole transcriptome analyses. Thanks to these types of studies, new ncRNAs have been identified for their implication in cardiac development and CVDs. In this review, we briefly describe the classification of ncRNAs into microRNAs, long ncRNAs, and circular RNAs. We then discuss their critical roles in cardiac development and CVDs by citing the most up-to-date research articles. More specifically, we summarize the roles of ncRNAs in the formation of the heart tube and cardiac morphogenesis, cardiac mesoderm specification, and embryonic cardiomyocytes and cardiac progenitor cells. We also highlight ncRNAs that have recently emerged as key regulators in CVDs by focusing on six of them. We believe that this review concisely addresses perhaps not all but certainly the major aspects of current progress in ncRNA research in cardiac development and CVDs. Thus, this review would be beneficial for readers to obtain a recent picture of key ncRNAs and their mechanisms of action in cardiac development and CVDs.

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Section: Pulmonary Hypertensionmentioning

confidence: 99%

Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases

Kawaguchi

Moukette

Hayasaka

et al. 2023

JCDD

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“…Three ncRNAs, miR-27b-3p, miR-21 and lncRNA SOX2-OT, promoted the proliferation of pulmonary artery smooth muscle cells (PASMCs) via downregulation of FBXW7 and WWP1 and upregulation of SUMO1 (109)(110)(111). The researchers revealed that overexpression of miR-27b-3p could significantly elevate GLI1 expression through inhibition of ubiquitin ligase FBXW7 expression and accelerating KLF5 accumulation by attenuating its ubiquitination degradation in rats in vivo (109). Notably, miR-21 overexpression facilitated chronic hypoxia-induced PASMC proliferation and pulmonary vascular remodeling, and the possible mechanism was that miR-21 negatively regulated the E3 ubiquitin ligase WWP1 and then activated TGF-b1 signaling in mice in vivo and in vitro (110).…”

Section: Crosstalk Between Ubiquitin Ligases and Ncrnas Drives In Hyp...mentioning

confidence: 99%

“…Moreover, five notable crosstalk pathways, circ-UBR4/miR-637/FOXO4, circ-UBR4/ miR-107/ROCK1, circ-UBR4/miR-491-5p/NRP2, circ-UBR4/ miR-185-5p/FRS2 and circ-CHFR/miR-214-3p/PAPPA axis, r e g u l a t e V S M C m i g r a t i o n a n d g r o w t h t o i m p r o v e atherosclerosis (75,(77)(78)(79)(80). Furthermore, regulating the MIAT/ EGLN2 axis and NEAT1/EGR1/RBM25 axis provides therapeutic strategies for ischemic stroke therapy (97,99), and ETAR/miR-27b-3p/FBXW7/KLF5/GLI1 axis and miRNA-146-5p/USP3 axis may act as potential targets for PAH prevention and treatment (109,114).…”

Section: Therapeutic Target Of Ups and Ncrnasmentioning

confidence: 99%

“…Accumulating evidence has illustrated that several miRNAs and lncRNAs are associated with the progression of PAH through the involvement of ubiquitination. Three ncRNAs, miR-27b-3p, miR-21 and lncRNA SOX2-OT, promoted the proliferation of pulmonary artery smooth muscle cells (PASMCs) via downregulation of FBXW7 and WWP1 and upregulation of SUMO1 ( 109 – 111 ). The researchers revealed that overexpression of miR-27b-3p could significantly elevate GLI1 expression through inhibition of ubiquitin ligase FBXW7 expression and accelerating KLF5 accumulation by attenuating its ubiquitination degradation in rats in vivo ( 109 ).…”

Section: Crosstalk Between Ubiquitin Ligases and Ncrnas Drives In Hyp...mentioning

confidence: 99%

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Crosstalk between ubiquitin ligases and ncRNAs drives cardiovascular disease progression

You,

Wen,

Tian

et al. 2024

Front. Immunol.

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Cardiovascular diseases (CVDs) are multifactorial chronic diseases and have the highest rates of morbidity and mortality worldwide. The ubiquitin–proteasome system (UPS) plays a crucial role in posttranslational modification and quality control of proteins, maintaining intracellular homeostasis via degradation of misfolded, short-lived, or nonfunctional regulatory proteins. Noncoding RNAs (ncRNAs, such as microRNAs, long noncoding RNAs, circular RNAs and small interfering RNAs) serve as epigenetic factors and directly or indirectly participate in various physiological and pathological processes. NcRNAs that regulate ubiquitination or are regulated by the UPS are involved in the execution of target protein stability. The cross-linked relationship between the UPS, ncRNAs and CVDs has drawn researchers’ attention. Herein, we provide an update on recent developments and perspectives on how the crosstalk of the UPS and ncRNAs affects the pathological mechanisms of CVDs, particularly myocardial ischemia/reperfusion injury, myocardial infarction, cardiomyopathy, heart failure, atherosclerosis, hypertension, and ischemic stroke. In addition, we further envision that RNA interference or ncRNA mimics or inhibitors targeting the UPS can potentially be used as therapeutic tools and strategies.

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Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling

Chai,

Wang,

Wang

et al. 2023

European Journal of Pharmacology

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Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension

Cited by 9 publications

References 50 publications

Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases

Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases

Crosstalk between ubiquitin ligases and ncRNAs drives cardiovascular disease progression

Downregulation of PDCD4 through STAT3/ATF6/autophagy mediates MIF-induced PASMCs proliferation/migration and vascular remodeling

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