2020
DOI: 10.1096/fasebj.2020.34.s1.05488
|View full text |Cite
|
Sign up to set email alerts
|

Induction of Glutathione Transferases and NAD(P)H Quinone Dehydrogenase 1 in Rats Dosed with Dichloroacetate

Abstract: Dichloroacetate (DCA) is an investigational drug for treatment of children and adults with genetic or acquired mitochondrial diseases and cancer. The pharmacokinetics and dynamics of DCA vary by subject age. For example, the chronic use of DCA in adults is associated with the development of reversible peripheral neuropathy, a side effect that is seldom observed in children, who metabolize DCA more quickly. The dechlorination of DCA to its inactive metabolite, glyoxylate, is catalyzed by maleylacetoacetate isom… Show more

Help me understand this report

This publication either has no citations yet, or we are still processing them

Set email alert for when this publication receives citations?

See others like this or search for similar articles