Induction of hair growth in alopecia totalis with diphencyprone sensitization

Abstract

The therapeutic use of the induction of an allergic contact sensitivity to diphencyprone in alopecia areata has been studied. Fourteen subjects had alopecia totalis and four had extensive and long-standing alopecia areata. Topical diphencyprone was capable of inducing an allergic contact sensitivity in 16 subjects (89%), and 13 of these agreed to proceed to repeated intermittent applications to the left side of the scalp, the right side acting as an untreated control; six subjects achieved cosmetically useful regrowth of normally pigmented terminal hair. No clinical features seemed to distinguish those who showed a favourable response from those who did not.

Topical Immunotherapy with Diphenylcyclopropenone Is Effective and Preferred in the Treatment of Periungual Warts

“…Distant or more widespread eczematous eruptions also occur, but such reactions usually disappear with topical steroid9,16,19,20. More rarely, contact urticaria16, erythema multiforme-like reactions21, influenza-like symptoms10,22 and vitiligo23 have been reported as well. We only experienced one patient which complained of aggravated itch that responded to systemic antihistamine.…”

Diphenylcyclopropenone in patients with alopecia areata. A critically appraised topic

“…Ten studies treated one side of the scalp with DPCP and compared it with no treatment on the other side of the scalp (half-head studies). [14][15][16][17][18][19][20][21][22][23] A single study compared DPCP vs. no treatment and tacrolimus 0Á1% vs. placebo. 24 A variety of AA types was included in the studies, mainly extensive and long-lasting alopecia totalis and alopecia universalis.…”

“…The strength of this critically appraised topic is in the extensive search; the participation of patients with alopecia in determining and rating the outcome measures; and the thorough Aghaei, 15 Ashworth et al, 16 Avgerinou et al, 17 Berth-Jones and Hutchinson, 18 Cotellessa et al, 19 Firooz et al, 20 Gordon et al, 21 Monk 15 Ashworth et al, 16 Avgerinou et al, 17 Berth-Jones and Hutchinson, 18 Cotellessa et al, 19 Gordon et al, 21 Monk, 22 Schuttelaar et al, 14 Aghaei, 15 Avgerinou et al, 17 Firooz et al, 20 Monk, 22 Schuttelaar et al, 14 van der Steen et al 23 k Aghaei, 15 Avgerinou et al, 17 Cotellessa et al, 19 Hunter et al, 25 van der Steen et al, 23 Schuttelaar et al 14 l Avgerinou et al, 17 Berth-Jones and Hutchinson, 18 Hunter et al, 25 Schuttelaar et al 14 application of the GRADE method with detailed evaluation and reporting, which included a risk of bias assessment of individual studies, as well grading the quality of evidence for each outcome taking into account any limitations in study design or execution inconsistencies in the results, indirectness of the evidence, imprecision and publication bias. The British Association of Dermatologists' guideline on AA only included studies up to 2001 and did not perform a critical appraisal of the included studies.…”

Topical immunotherapy with diphencyprone in Indians with alopecia areata

“…Sensitisation with DPC was performed as previously described 4 . This was with 2% DPC in acetone applied to a 2.5 cm 2 area of the left half of the scalp; rechallenge was carried out 10 days later with 0.1% DPC on the right half of the scalp.…”