Induction of hapten-specific immunological tolerance and immunity in B lymphocytes

Fidler, John M.

doi:10.1016/0008-8749(85)90106-6

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…It has shown that it can elicit immunologic responses; induce generation of inflammatory bowel disease (IBD). [1213] This model shares many of the histopathological and clinical features of human IBD and is useful for the study of the etiopathogenesis of chronic colon inflammation as well as providing an inexpensive model suitable for assessing therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease

Patel¹,

Patel²,

Patel³

2010

Journal of Young Pharmacists

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The present study was designed to evaluate the effects of aqueous extract of Ficus bengalensis Linn. bark (AEFB) on inflammatory bowel disease (IBD). Effects of AEFB were studied on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on first day only)-induced IBD in rats. Effects of co-administration of prednisolone (2 mg/kg) and AEFB (250, 500 mg/kg) for 21 days were also evaluated. Various physical parameters including body weight, food, and water intake measured on 1st and 21st days. At end of the experiment, various histopathological indexes are assessed. The colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and nitric oxide (NO) levels and % mast cell protection in mesentery were also measured. In our study, we found that AEFB has a significant protective effect in the inflammatory bowel disease as compared to prednisolone in rats.

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Section: Discussionmentioning

confidence: 99%

Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease

Patel¹,

Patel²,

Patel³

2010

Journal of Young Pharmacists

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show abstract

“…It has been shown that it can elicit immunologic responses and induce generation of IBD. [1314] This model shares many of the histopathological and clinical features of human IBD and is useful for the study of the etiopathogenesis of chronic colon inflammation as well as providing an inexpensive model suitable for assessing new therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease

Patel¹,

Patel²

2010

Indian J Pharmacol

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Objective:The present study was designed to evaluate the effects of ethanol extract of Ficus bengalensis Linn. bark (AEFB) on inflammatory bowel disease (IBD).Materials and Methods:Effects of AEFB were studied on 2,4,6-trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on first day only) induced IBD in rats. The effects of co-administration of prednisolone (2 mg/kg) and AEFB (250, 500 mg/kg) for 21 days were evaluated. Animals sacrificed at end of the experiment and various histopathological parameters like colon mucosal damage index (CMDI) and disease activity index (DAI) were assessed. In the colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and nitric oxide (NO) levels and in mesentery % mast cell protection was also measured.Results:Rats treated with only TNBS showed more score of CMDI and DAI, higher MDA, NO, MPO, and lower SOD activity as compared to the control group. Treatment with AEFB significantly declined both indices scores and decreased the MPO, MDA, NO, and increased the SOD activity. AEFB also increased the % mast cell protection compared to alone TNBS-treated animals.Conclusion:In our study, we found that AEFB has a significant protective effect in the IBD in rats that is comparable to that of prednisolone and may be because of the presence of flavonoids, terpenoids, and phenolic compounds.

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“…It has shown that it can elicit immunologic responses, induce generation of inflammatory bowel disease (IBD). [1516] This model shares many of the histopathological and clinical features of human IBD and is useful for the study of the etiopathogenesis of chronic colon inflammation as well as providing an inexpensive model suitable for assessing therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation

Patel¹,

Patel²,

Shah³

2010

Journal of Young Pharmacists

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The present study was undertaken to study the role of PAR-2 receptor activation in pathophysiology of intestinal inflammation. Inflammatory bowel disease was induced in Wistar albino rats by intrarectal administration of 2, 4, 6 trinitrobenzenesulfonic acid (TNBS, 0.25 ml 120 mg/ml in 50% ethanol intrarectally, on 1st day only). Trypsin (500 μg/kg, 1 mg/kg, 5 mg/kg, intrarectal) was given from the same day up to 20 days. Various physical parameters including body weight, food and water intake were measured on 1st and 20th days. At end of the experiment, colon weight and various histopathological indexes were assessed. The colon homogenate malondialdehyde (MDA), myeloperoxidase (MPO), and superoxide dismutase (SOD) and % mast cell protection in mesentery were also measured. Trypsin at higher dose (5 mg/kg) showed the higher level of oxidative enzymes and lower level of protective enzymes as compared to the animals treated with only TNBS. Trypsin treatment produced significantly more mast cell degranulation. Finally in the histopathology, there was increased in severity of the disease in trypsin-treated animals. The role of PAR-2 (protease activated receptor-2) receptor in gut is pro-inflammatory and thus appears as a new potential therapeutic target for inflammatory bowel disease treatments.

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Induction of hapten-specific immunological tolerance and immunity in B lymphocytes

Cited by 9 publications

References 31 publications

Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease

Aqueous Extract of Ficus bengalensis Linn. Bark for Inflammatory Bowel Disease

Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease

Investigation of Possible Role of the PAR-2 Receptor in Intestinal Inflammation

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