Induction of hepatic carcinoma with aflatoxin in the rhesus monkey

Gopalan, C.; Tulpule, P. G.; Krishnamurthi, D.

doi:10.1016/s0015-6264(72)80086-5

Cited by 24 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early studies found that rhesus monkeys were susceptible to AFB 1 carcinogenicity. In three reports each on single animals, two cases of HCC (Adamson et al, 1976;Gopalan et al, 1972;Sieber et al, 1979) and one of cholangiocarcinoma (Tilak, 1975) were observed in animals treated for up to 6 years with an oral or a combined oral and im dosing regimen. More recent data on 47 monkeys, representing three species (rhesus, cynomolgus, and African green) that had received AFB 1 by ip and/or oral routes for periods greater than 2 months, have been published (Thorgeirsson et al, 1994).…”

Section: Experimental Aflatoxin Carcinogenesismentioning

confidence: 99%

Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

Kensler¹,

Roebuck²,

Wogan³

et al. 2010

Toxicological Sciences

581

509

View full text Add to dashboard Cite

Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically developing world. The adverse toxicological consequences of these compounds in populations are quite varied because of a wide range of exposures leading to acute effects, including rapid death, and chronic outcomes such as hepatocellular carcinoma. Furthermore, emerging studies describe a variety of general adverse health effects associated with aflatoxin, such as impaired growth in children. Aflatoxin exposures have also been demonstrated to multiplicatively increase the risk of liver cancer in people chronically infected with hepatitis B virus (HBV) illustrating the deleterious impact that even low toxin levels in the diet can pose for human health. The public health impact of aflatoxin exposure is pervasive. Aflatoxin biomarkers of internal and biologically effective doses have been integral to the establishment of the etiologic role of this toxin in human disease through better estimates of exposure, expanded knowledge of the mechanisms of disease pathogenesis, and as tools for implementing and evaluating preventive interventions.

show abstract

Section: Experimental Aflatoxin Carcinogenesismentioning

confidence: 99%

Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

Kensler¹,

Roebuck²,

Wogan³

et al. 2010

Toxicological Sciences

581

509

View full text Add to dashboard Cite

show abstract

“…Most of the fungal contaminant can cause spoilage and they are known to produce mycotoxins which are detrimental to human health. Aflatoxin, a group of toxic metabolites produced by certain Aspergillus species have been found to be carcinogenic, tetragenic and mutagenic to several species of experimental animals (Butler and Barnes 1998, Gopalan et al, 1972and Adamson et al, 1973. Now despite the consumer acceptability of drinks from H. sabdariffa calyxes and physiochemical evaluation of the "zobo", (Amusa et al, 2005, Osuntogun andAboaba 2004) inhibition of fungal isolates from sorrel drinks (Ilondu and Iloh 2007), fermentation studies on Roselle (Ojokoh et al, 2002), research has not been done on the microorganism that causes H. sabdariffa calyxes deterioration during storage.…”

Section: Introductionmentioning

confidence: 99%

Microbial quality and proximate composition of dried Hibiscus sabdariffa calyxes in Uyo, Eastern Nigeria

Adebayo-Tayo¹,

Samuel²

2009

MJM

View full text Add to dashboard Cite

“…The pathogenesis of spontaneous hepatocellular carcinoma (HCC) is not well-established in nonhuman primates due to its low incidence, though the occurrence is often associated with cirrhosis and hepatitis virus infection in humans 12,13 . W h e r e a s se ver a l c h e m i c a l s , s uc h a s 2 -a m i n o -3-methylimidazo [4,5-f] quinoline 14 , pyridoxine 15 , cycasin 16 , aflatoxin B 1 17,18 , and N-nitrosodiethylamine 19,20 , can induce hepatic tumor in laboratory primates, only limited information is available from these experimentally-induced liver tumors in monkey. In the safety assessment of new ch em icals or d rug s, it is im po rtan t to r eco gnize spontaneous lesions in laboratory monkeys, especially in young monkeys that are routinely used in toxicological studies.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey.

Yoshizawa

Oishi²,

Sano³

et al. 2002

J Toxicol Pathol

View full text Add to dashboard Cite

Hepatocellular carcinoma which occurred in one male laboratory cynomolgus monkey at 5 years of age was investigated extensively by immunological, histopathological and electron-microscopic examinations. The animal exhibited no abnormalities in clinical laboratory tests including blood-chemistry, except for elevation of protein induced by vitamin K absence or antagonist II (PIVKA-II) in serum, which is one of the hepatic tumor markers. In virus antibody tests, the serum was positive for hepatitis A virus. On necropsy, a mass measuring 60 × 60 × 65 mm was seen in the hepatic left lobe. The tumor mass had a lobulated structure with hemorrhagic and necrotic areas, and was demarcated by thin fibrous capsules. Histopathologically, the tumor was composed of hepatocyte-like cells, having irregular trabecular structure with various thickness, lined by vascular endothelial cells. Cellular atypia such as polynucleated cells, mitotic figures, and invasion into the vascular cavity were also observed. Immunohistochemically, the tumor cells showed positive reaction for anti-PIVKA-II, anti-epithelial membrane antigen (EMA), anti-carcinoembryonic antigen (CEA), and anti-cytokeratin 18, as well as for proliferating cell nuclear antigen (PCNA). On electron-microscopic examination, the tumor cells had a number of tight junctions and formations of bile canaliculi between adjacent cells, basically resembling hepatocytes. This is the first case of hepatocellular carcinoma with PIVKA-II production in monkeys. Serological and immunohistochemical analyses for PIVKA-II are, therefore, practicable for diagnose as hepatocellular carcinoma in nonhuman primates. (J Toxicol Pathol 2002; 15: 61-68)

show abstract

Induction of hepatic carcinoma with aflatoxin in the rhesus monkey

Cited by 24 publications

References 5 publications

Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

Microbial quality and proximate composition of dried Hibiscus sabdariffa calyxes in Uyo, Eastern Nigeria

Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey.

Contact Info

Product

Resources

About