Induction of hepatocellular carcinoma in mice and the role of melatonin

Abdel-Mawla, Ashour A.; Fadali, Geylan A.; Youssef, Eman; Eliwa, Hoda

doi:10.1016/j.jobaz.2012.12.004

Cited by 7 publications

(6 citation statements)

References 59 publications

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“…The authors concluded that melatonin protects hepatic cells against carcinogens via anti-proliferative and antiangiogenic functions. 51 Zhao et al observed similar protective effects of melatonin in pituitary cells treated with diethylstilbestrol. 52 Xie et al showed that the combination of IL-4 and melatonin ameliorated the inflammation caused by glucose and IL-1β in human retinal cells.…”

Section: Antiangiogenic Functionmentioning

confidence: 79%

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Mirza‐Aghazadeh‐Attari

Reíter

Rikhtegar

et al. 2020

IUBMB Life

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, a pleotropic molecule with a wide distribution, has received considerable attention in recent years, mostly because of its various major effects on tissues or cells since it has both receptor-dependent and receptor-independent actions over a wide range of concentrations. These biological and physiological functions of melatonin include regulation of circadian rhythms by modulating the expression of core oscillator genes, scavenging the reactive oxy-

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Section: Antiangiogenic Functionmentioning

confidence: 79%

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Mirza‐Aghazadeh‐Attari

Reíter

Rikhtegar

et al. 2020

IUBMB Life

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“…In mouse hepatoma H22 cells, phosphorylation of m-TOR and Akt were reduced by melatonin leading to augmented Beclin-1 expression that intensified autophagy [80]. In an in vivo model, Abdel-Mawla et al [81] observed a reduction of VEGF and PCNA gene expression in mice with 2-nitropropane-induced hepatocellular cancer treated with 10 mg/kg of melatonin. The conclusion they reached is that hepatic cells were protected by melatonin against carcinogens through its antiproliferative and antiangiogenic functions.…”

Section: Melatonin Antiangiogenic Actions and Cancermentioning

confidence: 99%

Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments

González

Alonso‐González

González-González

et al. 2021

Cancers

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Melatonin is a hormone with different functions, antitumor actions being one of the most studied. Among its antitumor mechanisms is its ability to inhibit angiogenesis. Melatonin shows antiangiogenic effects in several types of tumors. Combination of melatonin and chemotherapeutic agents have a synergistic effect inhibiting angiogenesis. One of the undesirable effects of chemotherapy is the induction of pro-angiogenic factors, whilst the addition of melatonin is able to overcome these undesirable effects. This protective effect of the pineal hormone against angiogenesis might be one of the mechanisms underlying its anticancer effect, explaining, at least in part, why melatonin administration increases the sensitivity of tumors to the inhibitory effects exerted by ordinary chemotherapeutic agents. Melatonin has the ability to turn cancer totally resistant to chemotherapeutic agents into a more sensitive chemotherapy state. Definitely, melatonin regulates the expression and/or activity of many factors involved in angiogenesis which levels are affected (either positively or negatively) by chemotherapeutic agents. In addition, the pineal hormone has been proposed as a radiosensitizer, increasing the oncostatic effects of radiation on tumor cells. This review serves as a synopsis of the interaction between melatonin and angiogenesis, and we will outline some antiangiogenic mechanisms through which melatonin sensitizes cancer cells to treatments, such as radiotherapy or chemotherapy.

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“…15 Experts estimate that obesity causes about 20% of all cancer cases. 14,15,17 Epidemiological studies show that obesity was associated with an increased risk of cancer. 16,18 One of the cancers thought to occur due to obesity was hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…16,18 One of the cancers thought to occur due to obesity was hepatocellular carcinoma. 13,17,19 Obesity causes dysregulation of growth signals such as increased insulin and leptin. [20][21][22] Obesity causes angiogenesis, tumorigenesis and chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Moringa oleifera fruit extract as a potential antioxidant against liver injury by 2-Nitropropane induction in obese male mice model: pre-clinical study

et al. 2023

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Background: Moringa oleifera fruit extract contains beneficial chemical compounds. This study was conducted to observed the power of antioxidant against liver injury by 2-Nitropropane induction in an obese male mice model. Methods: This research was in vivo laboratory experimental study with a post-test control design group only. The population was obese male mice models, Swiss strain, aged 6–8 weeks, weighing between 60–80 gr. The research sample was determined by Federer's formula for a complete randomized design experimental test, group N (control), O1 (induced by 2-Nitropropane intraperitoneal (i.p) once), O2 (induced by 2-Nitropropane i.p twice), P1 (induced by 2-Nitropropane i.p. once and gavage with M. oleifera fruit extract 500mg/kg bodyweight (BW) once a day), P2 (induced by 2-Nitropropane i.p. twice and gavage of M. oleifera fruit extract 500mg/kg BW once a day), and P3 (induced by 2-Nitropropane i.p. twice and gavage of vitamin C 500mg/kg BW once a day). Antioxidant potential parameters were measured by levels of malondialdehide (MDA), glutation (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG), catalase activity, manganese superoxide dismutase (MnSOD), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT). This research was held at the Biochemistry laboratory of Medicine Faculty, UPN Veteran Jakarta in May–September 2020. Analysis was carried out using SPSS version 20.0. The parameters were tested using ANOVA. Results: MDA levels decreased, GSH increased, 8-OHdG decreased, catalase activity increased, MnSOD activity increased and SGOT, SGPT levels decreased. M. oleifera fruit extract was statistically proven to be a candidate for potential antioxidant against liver injury of 2-Nitropropane induction in obese male mice model. Conclusions: M. oleifera fruit extract was statistically evident as an antioxidant substance that reduces oxidative stress in acute liver injury caused by 2-Nitropropane induction.

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Induction of hepatocellular carcinoma in mice and the role of melatonin

Cited by 7 publications

References 59 publications

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Melatonin: An atypical hormone with major functions in the regulation of angiogenesis

Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments

Moringa oleifera fruit extract as a potential antioxidant against liver injury by 2-Nitropropane induction in obese male mice model: pre-clinical study

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