Induction of high expression of CCR7 and high production of IL-12 in human monocyte-derived dendritic cells by a new bacterial component: LCOS 1013

Gillet-Hladky, Stéphanie; Duperrier, Karine; Picandet, Stephanie; Mathias, Virginie; Carvalho, Miranda Camila de; Bernaud, Janine; Masseau, Daniel; Bienvenu, Jacques; Rigal, Dominique

doi:10.1016/j.intimp.2008.02.007

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…The HPA-axis plays an important role in the pathogenesis and course of inflammatory diseases (36). In HCV: hepatitis C virus; HCMV: human cytomegalovirus; SAA: serum amyloid A; hBD-3: human beta-defensin-3; LTA: lipoteichoic acid; PG: peptidoglycan; ND: not determined; HSV1: herpes simplex virus 1; LMW-HA: low molecular weight -hyaluronic acid; LPS: lipopolysaccharide; RSV: respiratory syncytial virus; MMTV: mouse mammary tumor virus (9,(119)(120)(121)(122)(123)(124)(125)(126)(127)(128)(129)(130)(131)(132)(133)(134).…”

Section: Tlrs and The Hypothalamic-pituitaryadrenal(hpa)-axismentioning

confidence: 99%

Innate immunity, coagulation and surgery

Koch

Zacharowski²,

Boehm³

et al. 2009

Front Biosci

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Inflammation is the host's defense mechanism to infection or trauma including surgical procedures. In the clinic, non-infectious inflammation plays an important part in cardiology (e.g. Percutaneous transluminal coronary angioplasty, PTCA), intensive care medicine (e.g. polytrauma), cardiac (e.g. extracorporeal circulation) and vascular surgery (e.g. reperfusion injury). An imbalance of the inflammatory response can cause an acute condition like sepsis or long-term Cardiovascular disease (CVD), both of which are leading killers in the Western world. Alterations in coagulation, innate immunity and endothelial function represent key aspects in the mechanism of inflammation and are the link between the pathogenesis of these two diseases. Studying inflammatory pathways or targeting specific mediators during inflammation may help to develop strategies to improve the clinical outcome of patients undergoing major surgery, where postoperative inflammation plays a crucial role.

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Section: Tlrs and The Hypothalamic-pituitaryadrenal(hpa)-axismentioning

confidence: 99%

Innate immunity, coagulation and surgery

Koch

Zacharowski²,

Boehm³

et al. 2009

Front Biosci

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“…As the result of maturation, DCs decrease phagocytosis and increase the expression MHC‐I, MHC‐II and co‐stimulatory molecules, which are surface molecules required for the activation of antigen‐specific naive T cells . Maturing DCs also secrete cytokines that contribute to defining the nature and polarization of the effector function of T cells after recognition of peptide–MHC on the DC surface . Mature DCs acquire the capacity to migrate from peripheral sites of infection to the lymph nodes, where naive T cells reside .…”

Section: Introductionmentioning

confidence: 99%

Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity

et al. 2012

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Summary Innate and adaptive immunity are inter‐related by dendritic cells (DCs), which directly recognize bacteria through the binding of pathogen‐associated molecular patterns (PAMPs) to specialized receptors on their surface. After capturing and degrading bacteria, DCs present their antigens as small peptides bound to MHC molecules and prime naive bacteria‐specific T cells. In response to PAMP recognition DCs undergo maturation, which is a phenotypic change that increases their immunogenicity and promotes the activation of naive T cells. As a result, a specific immune response that targets bacteria‐derived antigens is initiated. Therefore, the characterization of DC–bacteria interactions is important to understand the mechanisms used by virulent bacteria to avoid adaptive immunity. Furthermore, any impairment of DC function might contribute to bacterial survival and dissemination inside the host. An example of a bacterial pathogen capable of interfering with DC function is Salmonella enterica serovar Typhimurium (S. Typhimurium). Virulent strains of this bacterium are able to differentially modulate the entrance to DCs, avoid lysosomal degradation and prevent antigen presentation on MHC molecules. These features of virulent S. Typhimurium are controlled by virulence proteins, which are encoded by pathogenicity islands. Modulation of DC functions by these gene products is supported by several studies showing that pathogenesis might depend on this attribute of virulent S. Typhimurium. Here we discuss some of the recent data reported by the literature showing that several virulence proteins from Salmonella are required to modulate DC function and the activation of host adaptive immunity.

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“…In contrast, upon recognition of invasive pathogenic bacteria and pro-inflammatory signals, DCs mature, secrete IL-12 and induce the activation and effector function of bacteria-specific T cells [69][70][71][72]. In most cases, cellular and humoral adaptive immune responses will be required to efficiently clear both extracellular and intracellular bacteria [73].…”

Section: Introductionmentioning

confidence: 99%

Use of Genetically Modified Bacteria to Modulate Adaptive Immunity

Bueno

González²,

Kalergis³

2009

CGT

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Infectious diseases caused by virulent bacteria are a significant cause of morbidity and mortality worldwide, especially in developing countries. However, attenuated strains derived from pathogenic bacteria, such as Salmonella, are highly immunogenic and can be used as vaccines to promote immunity against parental pathogenic bacteria strains. Further, they can be genetically manipulated to either express foreign antigens or deliver exogenous DNA, in order to induce immunity against other pathogens or antigens. Contrarily, specific structural modifications in attenuated Salmonella have allowed the generation of strains that can be well tolerated by the immune system and reduce inflammatory responses. It is thought that those strains could be considered as vectors to promote specific immune tolerance for certain auto-antigens or allergens and reduce unwanted or self-reactive immune responses. In addition, some structural features of Salmonella can contribute to defining the nature and type of polarization of the adaptive immune response induced after immunization, which can be considered as a tool to modulate antigen-specific immunity. In this article we discuss recent advances in the understanding of immune system modulation by molecular components of bacteria and their exploitation for the rational induction of pathogen immunity or antigen-specific tolerance.

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Induction of high expression of CCR7 and high production of IL-12 in human monocyte-derived dendritic cells by a new bacterial component: LCOS 1013

Cited by 5 publications

References 42 publications

Innate immunity, coagulation and surgery

Innate immunity, coagulation and surgery

Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity

Use of Genetically Modified Bacteria to Modulate Adaptive Immunity

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