Induction of Hyporesponsiveness in Human Lymphocytes-T Despite Their Expression of both the Co-receptor CD28 and Its Ligand B7

Friccius, Hilke; Siegels-Hübenthal, Petra; Rehbein, Arnika; Schlotz, Elke; Pawelec, Graham

doi:10.1006/cimm.1993.1238

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We could therefore have missed the possible transient down-regulation of CD28 on CD4"ĉ ells. Secondly, the CD28 co-stimulatory pathway involves several other molecules such as CTLA-4 [32] and their ligands CD86 (B7-2) and CD80 (B7-1), which may also be involved in antigen-specific hyporesponsiveness. Indeed, antigen presentation in the absence of CD86/CD80 co-stimulation leads to T cell anergy [3,7].…”

Section: Discussionmentioning

confidence: 99%

CD28 expression is increased in venom allergic patients but is not modified by specific immunotherapy

Tsicopoulos¹,

LABALETTE²,

AKOUM³

et al. 1996

Clin Exp Allergy

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

CD28 expression is increased in venom allergic patients but is not modified by specific immunotherapy

Tsicopoulos¹,

LABALETTE²,

AKOUM³

et al. 1996

Clin Exp Allergy

View full text Add to dashboard Cite

show abstract

“…The normal function of the CD28 molecule on T cells is to interact with its ligand, the B7 molecule, on antigen-presenting cells. When the T cell recognizes antigen via the T-cell antigen receptor, triggering of the CD28 molecule provides a costimulatory second signal which is required for activation (2,4). Stimulation of T cells via the antigen receptor in the absence of a secondary costimulatory signal such as CD28 results in T-cell anergy (15).…”

mentioning

confidence: 99%

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients

Crucian

Dunne

Friedman

et al. 1995

Clin Diagn Lab Immunol

View full text Add to dashboard Cite

A comprehensive peripheral blood immunophenotype analysis of 16 multiple sclerosis (MS) patients was performed by three-color flow cytometric analysis, and the results were compared with those for age-matched healthy controls. The cell subsets quantified included T cells (CD3 ؉), B cells (CD19 ؉), NK cells (CD56 ؉), CD4 ؉ and CD8 ؉ T cells, cytotoxic (CD28 ؉) and suppressor precursor (CD28 ؊) CD8 ؉ T cells, CD45RA ؉ and CD45RO ؉ T cells (CD4 ؉ and CD8 ؉), and CD5 ؉ T and B cells. Analysis of MS patients' peripheral blood revealed essentially normal levels of total T, B, and NK cells. In agreement with results obtained by other investigators, it was found that MS patients had an increased CD4/CD8 ratio, primarily due to a decrease in CD8 ؉ T cells. MS patients were found to have a significantly decreased level of suppressor precursor (CD28 ؊) CD8 ؉ T cells compared with that of controls but to have normal levels of cytotoxic (CD28 ؉) CD8 ؉ T cells. These data indicate that MS patients do not have a general decrease in CD8 ؉ T cells but that they have a specific decrease in the suppressor precursor subset only and normal levels of cytotoxic CD8 ؉ T cells. MS patients also had a significant increase in memory (CD45RO ؉) CD4 ؉ T cells and displayed a trend towards a decrease in naive (CD45RA ؉) T cells in the peripheral blood.

show abstract

Role of three quantitatively dominant endogenous peptides from HLA-DRB1∗0401 molecules in class II specific alloreactivity

Adibzadeh

Friccius²,

Bornhak

et al. 1994

Transplant Immunology

View full text Add to dashboard Cite

Induction of Hyporesponsiveness in Human Lymphocytes-T Despite Their Expression of both the Co-receptor CD28 and Its Ligand B7

Cited by 5 publications

References 0 publications

CD28 expression is increased in venom allergic patients but is not modified by specific immunotherapy

CD28 expression is increased in venom allergic patients but is not modified by specific immunotherapy

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients

Role of three quantitatively dominant endogenous peptides from HLA-DRB1∗0401 molecules in class II specific alloreactivity

Contact Info

Product

Resources

About