Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema–dermatitis syndrome

Viljanen, Mirva; Pohjavuori, Emma; Haahtela, Tari; Korpela, Riitta; Kuitunen, Mikael; Sarnesto, Annikki; Vaarala, Outi; Savilahti, Erkki

doi:10.1016/j.jaci.2005.03.047

Cited by 134 publications

(109 citation statements)

References 43 publications

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“…In immunocompromised patients, a combination of L. casei, B. breve and prebiotic galactooligosaccharides [26] and B. longum [30] have reduced serum CRP levels and also resulted in improvement in the overall clinical appearance of chronic inflammation [30] . In contrast to the studies above and to our results in the present study, Lactobacillus rhamnosus GG increased serum hsCRP levels compared to placebo in infants with IgE-associated atopic eczema dermatitis syndrome [28] . However, L. rhamnosus GG had no effect on serum CRP levels in patients with rheumatoid arthritis [29] .…”

Section: Discussioncontrasting

confidence: 99%

“…shermanii JS were both good inducers of anti-inflammatory cytokines, whereas L. rhamnosus GG was a rather poor inducer of any cytokine. Previously, the effect of probiotics on CRP has only been studied in immunocompromised patients [23][24][25][26][27] , allergic children [28] and patients suffering from rheumatoid arthritis [29] . In immunocompromised patients, a combination of L. casei, B. breve and prebiotic galactooligosaccharides [26] and B. longum [30] have reduced serum CRP levels and also resulted in improvement in the overall clinical appearance of chronic inflammation [30] .…”

Section: Discussionmentioning

confidence: 99%

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Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Kekkonen

Lummela²,

Karjalainen³

et al. 2008

WJG

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184

152

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freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS:The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo.IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION:In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Kekkonen

Lummela²,

Karjalainen³

et al. 2008

WJG

Self Cite

184

152

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“…136,137 In addition, the induction of low-grade infl ammation, as indicated by increased serum CRP and IL-6 levels, has been proposed as a mechanism. 130 Note, however, that in the above study, serum cytokine concentrations were below the detection limit in the majority of samples, including in almost 80% of the IL-6 samples. In the other studies, suffi cient blood samples were available only from subsets of study participants and no information was provided on how representative these children were of the whole study population.…”

Section: Probiotics In Allergic Diseasescontrasting

confidence: 58%

“…Induction of low-grade infl ammation has also been proposed as a mechanism for therapeutic effects of probiotic supplementation in atopic dermatitis. 130 Interestingly, in that trial the very same combination of probiotics was used, but without added prebiotic, and was not found to have an infl ammatory effect but to also increase serum IL-10 levels. In contrast, treatment with LGG alone was associated with increased serum CRP and IL-6 concentrations in the subgroup of children with IgE-associated atopic eczema/ dermatitis syndrome.…”

Section: Probiotics In Allergic Diseasesmentioning

confidence: 98%

Probiotics and immunity

et al. 2009

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Probiotics are defi ned as live microorganisms that, when administered in adequate amounts, confer a health benefi t on the host, including the gastrointestinal tract. While this benefi cial effect was originally thought to stem from improvements in the intestinal microbial balance, there is now substantial evidence that probiotics can also provide benefi ts by modulating immune functions. In animal models, probiotic supplementation is able to provide protection from spontaneous and chemically induced colitis by downregulating infl ammatory cytokines or inducing regulatory mechanisms in a strain-specifi c manner. In animal models of allergen sensitization and murine models of asthma and allergic rhinitis, orally administered probiotics can straindependently decrease allergen-specifi c IgE production, in part by modulating systemic cytokine production. Certain probiotics have been shown to decrease airway hyperresponsiveness and infl ammation by inducing regulatory mechanisms. Promising results have been obtained with probiotics in the treatment of human infl ammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants. However, the fi ndings are too variable to allow fi rm conclusions as to the effectiveness of specifi c probiotics in these conditions.

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“…Lactobacillus rhamnosus GG (ATCC 53103) Prevention and treatment of various gastrointestinal disorders, especially diarrhoea, 24,25 immunomodulation in vitro 26 and in clinical studies 27,28 Lactobacillus rhamnosus Lc705 (DSM 7061)…”

Section: Probiotic Strain Specific Characteristicsmentioning

confidence: 99%

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

Kajander

Krogius-Kurikka

Rinttilä

et al. 2007

Aliment Pharmacol Ther

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Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema–dermatitis syndrome

Cited by 134 publications

References 43 publications

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults

Probiotics and immunity

Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome

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