INDUCTION OF INTERSTITIAL NEPHRITIS IN RATS FED PHENACETIN AND NAPA (N‐ACETYL‐p‐AMINOPHENOL)

The Renal Concentrating Capacity in Albino Rats after Long‐term Consumption of Phenacetin, NAPA (N‐acetyl‐p‐aminophenol) and Acetylsalicylic Acid

“…This dosage was estimated to be the highest dose without general toxic effects. In an earlier experiment the intended dose was 0.5 g/kg body weight, but the rats developed hyperphagia, lost weight, got massive intestinal bleedings and died prematurely (1). In the present study the acetylsalicylic group was similar in dietary intake and weight curve to the other groups.…”

“…As NAPA is a metabolite of phenacetin it is reasonable to suspect that NAPA should also have a nephrotoxic effect. A few experimental studies have been made suggesting that NAPA causes lesions similar to those from phenacetin (1,2,5).…”

“…During recent years several investigators have presented clinical data indicating a nephrotoxic effect from phenacetin (3, 7, 8,9,11,12,14). There are also animal experiments suggesting such an effect (1,2,10,15). T h e animal studies a r e mainly morphologic examinations of the kidneys after feeding phenacetin.…”