Induction of Labor in Women with Oligohydramnios: Misoprostol Compared with Prostaglandin E2

Objective: To evaluate the association of induction method on delivery mode in pregnancies complicated by oligohydramnios with and without fetal growth restriction (FGR). Methods: This was a secondary analysis of a National Institutes of Health funded retrospective cohort study of singleton deliveries at a tertiary-care hospital between 2002 to 2013 with diabetes, mild hypertension, and/or FGR. Chart abstraction was performed by trained research nurses. Patients with a diagnosis of fetal oligohydramnios with and without FGR were identified. Our analytic cohort was further stratified into three groups per initial induction agent: prostaglandins alone, prostaglandin plus mechanical ripening, or oxytocin only. Primary outcome was mode of delivery. Secondary outcomes included indications for cesarean delivery and neonatal morbidity. Results: Out of 4,929 patients in the original database, 546 subjects with fetal oligohydramnios were identified; of these 270 were induced and included for analysis. Outcomes were compared between 171 patients who had fetuses with isolated oligohydramnios and 99 patients who had fetuses with oligohydramnios and FGR. There were no significant differences in demographic characteristics between groups. Patients with fetuses with isolated oligohydramnios had similar rates of spontaneous vaginal delivery (SVD) when prostaglandins were used (n=44/79, 55.7% prostaglandin alone, n=44/76, 57.9% prostaglandin with mechanical ripening) and when they were not used (n=5/13, 38.5% oxytocin alone) (p=0.43). Similarly, the majority of patients in both cohorts underwent SVD regardless of induction method (n=30/44, 68.2% prostaglandin alone, n=30/44, 68.2% prostaglandin with mechanical ripening, and n=6/10, 60% oxytocin alone) (p=0.90). There was no significant difference in composite neonatal morbidity. Conclusion: In patients with fetuses with oligohydramnios with and without FGR, most patients delivered by SVD regardless of induction method. In this population, prostaglandin use was associated with a high chance of SVD in patients with fetuses with suspected placental insufficiency regardless of the presence of absence of FGR.

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“…A well-designed RCT should be performed to further clarify the inconsistencies in CD rates seen in certain studies. 8,9,13,15,17,21,22…”

Section: Research Implicationsmentioning

confidence: 99%

Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

et al. 2022

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Labor induction: change of indications and outcomes over time and future trends — a retrospective analysis

Omerović¹,

Pajek²,

Anzeljc³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: The purpose of this study was to evaluate the results of induction of labor over time in order to identify future trends. Methods: Data were collected from a national database for University Medical Center Maribor on the pregnant women demographics, the indications for labor induction, the process of induction and delivery, and the outcomes of delivery for periods 2011‒14 and 2015‒18. Results: In the second period (2015‒18), the rate of labor induction increased (14.7% vs. 19.0%, p < 0.00001), pregnant women were older (29.7 years vs. 30.0 years, p = 0.0018), were more frequently monitored in tertiary hospitals during pregnancy (40.6% vs. 80.7%, p < 0.00001), had hypertension in pregnancy (5.4% vs. 2.7%, p = 0.0002), and oligohydramnios (9.6% vs. 6.9% , p = 0.007). During labor, amniotomies (60.3% vs. 53.7%, p = 0.0004), umbilical cord prolapses (1.2% vs. 0.1%, p = 0.0003), meconium amniotic fluids (12.7% vs. 8.8%, p = 0.0008), pathological CTG tracings (15.2% vs. 8.4%, p < 0.00001) were less frequent. There were less episiotomies (37.4% vs. 29.1%, p < 0.00001), vacuum extractions (4.2% vs. 2.8%, p = 0.049), while the rate of caesarean sections remained constant (15.0% vs. 16.6%, p = 0.23). Conclusions: There is a tendency toward increased induction of labor (IOL) rates, probably related to higher average age of women, but with better delivery outcomes. Our findings reflect local practice and cannot be generalized.

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Induction of Labor in Women with Oligohydramnios: Misoprostol Compared with Prostaglandin E2

Cited by 2 publications

References 20 publications

Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

Delivery Mode among Patients with Oligohydramnios with or without Fetal Growth Restriction by Induction Method

Labor induction: change of indications and outcomes over time and future trends — a retrospective analysis

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