Induction of labor with mifepristone, - A randomized, double-blind study versus placebo

Stenlund, PerMårten; Ekman, Gunvor; Aedo, A.-R.; Bygdeman, M.

doi:10.1080/j.1600-0412.1999.780910.x

Cited by 60 publications

(25 citation statements)

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“…In our study, we observed that mifepristone is associated with favorable outcome in 89 % of women (labor onset in 56 % and cervical ripening 33 %) within 48 h of administration of oral mifepristone. These observations are in accordance with the existing literature where a variable success rate of labor onset at 66-93 % has been observed in pregnant women [8][9][10][11][12][13][14][15]. Also, the effect of cervical ripening after use of mifepristone has been variable ranging from no statistically difference to statistically significant improvement (60-80 % of all cases) [16][17][18][19][20].…”

Section: Discussionsupporting

confidence: 80%

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

Sharma

Soni

et al. 2015

J Obstet Gynecol India

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Objective To investigate the role of ''mifepristone'' for induction of labor (IOL) in pregnant women with prior cesarean section (CS).Methods In this retrospective study, all pregnant women with prior CS who received oral mifepristone (400 mg) for IOL (as per clear obstetric indications) [group 1] were compared with pregnant women with prior CS who had spontaneous onset of labor (SOL) [group 2], with respect to incidence of vaginal delivery, CS, duration of labor, and various maternal and fetal outcomes. Results During the study period, 72 women received mifepristone (group 1) for IOL and 346 had SOL (group 2). In group 1 after mifepristone administration, 40 (55.6 %) women had labor onset, and 24 (33.3 %) women had cervical ripening (Bishop Score C 8) within 48 h. There were no statistically significant differences with respect to duration of labor (p value: 0.681), mode of delivery (i.e., normal delivery or CS-p value: 0.076 or 0.120, respectively), or maternal (blood loss or scar dehiscence/rupture uterus), or fetal outcomes (NICU admission) compared to women with previous CS with SOL (group 2). However,

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Section: Discussionsupporting

confidence: 80%

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

Sharma

Soni

et al. 2015

J Obstet Gynecol India

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“…According to various existing literature, the labor onset and cervical ripening observed. [8][9][10][11][12] There is need of oxytocin requirement for augmentation of labour is very minimum so there is very less chances of scar dehiscence and rupture uterus. Mifepristone initiate the labour as naturally, causes cervical ripening (by releasing NO),promote uterine contractions by forming gap junctions and increasing influx of calcium it also increases the prostaglandins release without acting as a direct uterotonic.…”

Section: Discussionmentioning

confidence: 99%

Role of mifepristone in induction of labour in pregnant women with previous lower section caesarean section with IUFD in late preterm and term pregnancies

Deora

Shetty

2017

Int J Reprod Contracept Obstet Gynecol

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Background: The objective of the study was to evaluate efficacy and safety of oral mifepristone for preinduction cervical ripening and induction of labour in late preterm and term pregnancies with previous caesarean section with intrauterine fetal demiseMethods: This prospective short term study was conducted at Umaid hospital SNMC Jodhpur Rajasthan January 2016 to November 2016. 100 subjects with previous uses beyond 34 week with intrauterine fetal demise and bishop’s score<6 were included. Tablet mifepristone 200mg was given orally after taking written in informed consent. The same dose was repeated after 24 hour according to bishop’s score. Analysis was done with respect to maternal outcome of vaginal delivery, CS, duration of labour.Results: Among 100 subjects, 97 delivered vaginally (97%) delivered within 72 hour of 1% dose. Improvement of bishop’s score was observed in 1 subject (1%), which later required augmentation by oxytocin followed by vaginal delivery.1 subject (2%) failed to respond and required caesarean section, 72 hour after given of 1st dose.Conclusions: Mifepristone can be used safely and effectively for induction of labour in previous one and two LSCS near term and term pregnancies to avoid CS rates.

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“…In six trials women in the two arms of the studies were given different interventions and therefore blinding was not feasible, or not attempted (Gittens 1996;Harper 2006;Meyer 2005;Newman 1997;Stenlund 1999). The lack of blinding in these studies may have affected some of the outcomes examined in the review.…”

Section: Risk Of Bias In Included Studiesmentioning

confidence: 99%

“…We included five studies in this comparison (Elliott 1998;Giacalone 1998;Lelaidier 1994;Stenlund 1999). Women in the mifepristone group were less likely to require further medication to induce labour compared with controls ((random-effects) RR 0.59, 95% CI 0.37 to 0.95).…”

Section: Primary Outcomesmentioning

confidence: 99%

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Different methods for the induction of labour in outpatient settings

Kelly

Alfirević

Norman

et al. 2009

Cochrane Database of Systematic Reviews

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Induction of labor with mifepristone, - A randomized, double-blind study versus placebo

Abstract: The results of the present study show that mifepristone is a simple and effective treatment for inducing labor in post-term women with an unripe cervix.

Cited by 60 publications

References 0 publications

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

A Retrospective Case–Control Study Evaluating the Role of Mifepristone for Induction of Labor in Women with Previous Cesarean Section

Role of mifepristone in induction of labour in pregnant women with previous lower section caesarean section with IUFD in late preterm and term pregnancies

Different methods for the induction of labour in outpatient settings

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