Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial)

Ham, David P. van der; Nijhuis, Jan G.; Mol, Ben Willem J.; Beek, Johannes J. van; Opmeer, Brent C.; Bijlenga, Denise; Groenewout, Mariette; Arabin, Birgit; Bloemenkamp, Kitty W. M.; Wijngaarden, Wim J. van; Wouters, M.G.A.J.; Pernet, Paula; Porath, Martina; Molkenboer, J.F.M.; Derks, Jan; Kars, Michael; Scheepers, Hubertina C.J.; Weinans, Martin J. N.; Woiski, Mallory; Wildschut, H. I. J.; Willekes, Christine

doi:10.1186/1471-2393-7-11

Cited by 46 publications

(28 citation statements)

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“…In contrast, a more proactive or sometimes even aggressive approach may lead to a poorer neonatal outcome 15 . Currently, major randomised controlled trials are investigating the best treatment regimen for women with pPROM (PPROMEXIL study, 36 PROMPT study 37 ) and hypertensive disorders (HYPITAT II study 38 ) between 34 and 37 weeks of gestation. The outcome of these studies might influence doctors’ behaviour in the future.…”

Section: Discussionmentioning

confidence: 99%

Trends in preterm birth: singleton and multiple pregnancies in the Netherlands, 2000-2007

Schaaf

Mol

Abu‐Hanna³

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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Please cite this paper as: Schaaf J, Mol B, Abu‐Hanna A, Ravelli A. Trends in preterm birth: singleton and multiple pregnancies in the Netherlands, 2000–2007. BJOG 2011; DOI: 10.1111/j.1471‐0528.2011.03010.x. Objective Several studies have reported increasing trends in preterm birth in developed countries, mainly attributable to an increase in medically indicated preterm births. Our aim was to describe trends in preterm birth among singleton and multiple pregnancies in the Netherlands. Design Prospective cohort study. Setting Nationwide study. Population We studied 1 451 246 pregnant women from 2000 to 2007. Methods We assessed trends in preterm birth. We subdivided preterm birth into spontaneous preterm birth after premature prelabour rupture of membranes (pPROM), medically indicated preterm birth and spontaneous preterm birth without pPROM. We performed analyses separately for singletons and multiples. Main outcome measures The primary outcome was preterm birth, defined as birth before 37 weeks of gestation, with very preterm birth (<32 weeks of gestation) being a secondary outcome. Results The risk of preterm birth was 7.7% and the risk of very preterm birth was 1.3%. In singleton pregnancies, the preterm birth risk decreased significantly from 6.4% to 6.0% (P < 0.0001), mainly as a result of the decrease in spontaneous preterm birth without pPROM (3.6–3.1%, P < 0.0001). In multiple pregnancies, the preterm birth risk increased significantly (47.3–47.7%, P = 0.047), mainly as a result of medically indicated preterm birth, which increased from 15.0% to 17.9% (P < 0.0001). Conclusion In the Netherlands, the preterm birth risk in singleton pregnancies decreased significantly over the years. The trend of increasing preterm birth risk reported in other countries was only observed in (medically indicated) preterm birth in multiple pregnancies.

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Section: Discussionmentioning

confidence: 99%

Trends in preterm birth: singleton and multiple pregnancies in the Netherlands, 2000-2007

Schaaf

Mol

Abu‐Hanna³

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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“…Induction of labor and delivery for PPROM after 34 weeks’ gestation is recommended because, compared to expectant management, expeditious delivery is associated with reduced maternal infection and need for neonatal intensive care without any increase in perinatal morbidity and mortality [25,96–97]. However there is currently wide variation in practice and additional trials are ongoing to firmly establish the benefit of induction of labor prior to 37 weeks in cases of PPROM [25,98–100]. In the setting of prolonged membrane rupture (>18 hours) at term, prophylactic antibiotics are not indicated if the mother is not colonized with GBS; however the CDC recommends starting GBS prophylaxis if GBS status is unknown [101].…”

Section: Preventionmentioning

confidence: 99%

Diagnosis and Management of Clinical Chorioamnionitis

Tita

Andrews

2010

Clinics in Perinatology

775

548

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Chorioamnionitis is a common complication of pregnancy associated with significant maternal, perinatal, and long-term adverse outcomes. Adverse maternal outcomes include postpartum infections and sepsis while adverse infant outcomes include stillbirth, premature birth, neonatal sepsis, chronic lung disease and brain injury leading to cerebral palsy and other neurodevelopmental disabilities. Research in the last two decades has expanded our understanding of the mechanistic links between intraamniotic infection and preterm delivery as well as morbidities of preterm and term infants. Recent and ongoing clinical research into better methods for diagnosing, treating and preventing chorioamnionitis is likely to have a substantial impact on short and long-term outcomes in the neonate. KeywordsChorioamnionitis; infection; pregnancy; management DefinitionChorioamnionitis or intraamniotic infection is an acute inflammation of the membranes and chorion of the placenta, typically due to ascending polymicrobial bacterial infection in the setting of membrane rupture. Chorioamnionitis can occur with intact membranes, and this appears to be especially common for the very small fastidious genital mycoplasmas such as Ureaplasma species and Mycoplasma hominis, found in the lower genital tract of over 70% of women [1]. Only rarely is hematogeneous spread implicated in chorioamnionitis, as occurs with Listeria monocytogenes [2]. When characteristic clinical signs are present, the condition is referred to as clinical chorioamnionitis or clinical intraamniotic infection. Although there is significant overlap between clinical and histologic chorioamnionitis, the latter is a more common diagnosis based on pathologic findings on microscopic examination of the placenta that encompasses clinically unapparent (sub-clinical) chorioamnionitis as well as clinical chorioamnionitis. Funisitis, also a histopathologic diagnosis, is the extension of infection or inflammation to the umbilical cord. Overall the definition of chorioamnionitis a Corresponding author for proof and reprints: Dr. Alan T. N. Tita (alan.tita@obgyn.uab.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Epidemiology (incidence and risk factors)Overall, 1-4% of all births in the US are complicated by chorioamnionitis [2]; however, the frequency of chorioamnionitis varies markedly by diagnostic criteria, specific risk factors and gestational age [3][4][5][6][7]. Chorioamnionitis (clinical and histologic combined), complicates as many as 40-70% of preterm births with premature membrane rupture or spontaneous la...

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“…While there is good evidence that for term PROM early delivery is associated with a lower incidence of maternal infection and increased maternal satisfaction compared with expectant management, 43 trials of optimal management of preterm PROM are still underway. 44,45 A recent review found insufficient evidence to support planned delivery when maternal diabetes is controlled. 1 Our data did not contain information on diabetes management, but a steep increase in uncontrolled diabetes seems an unlikely explanation for an increasing proportion of planned deliveries associated with diabetes.…”

Section: 39mentioning

confidence: 99%

Trends in planned early birth: a population-based study

Morris

Algert

Falster

et al. 2012

American Journal of Obstetrics and Gynecology

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were inductions. As planned births increased, maternal risks shifted, including a decline in inductions with maternal hypertension from 31.9% to 23.9%. Earlier birth was contemporaneous with increases (trend P<0.001) in neonatal and maternal morbidity from 3.0% to 3.2% and 0.9 % to 1.3%, respectively. Conclusion:Planned birth before the due date is increasing but without reducing perinatal deaths.

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Induction of labour versus expectant management in women with preterm prelabour rupture of membranes between 34 and 37 weeks (the PPROMEXIL-trial)

Cited by 46 publications

References 14 publications

Trends in preterm birth: singleton and multiple pregnancies in the Netherlands, 2000-2007

Trends in preterm birth: singleton and multiple pregnancies in the Netherlands, 2000-2007

Diagnosis and Management of Clinical Chorioamnionitis

Trends in planned early birth: a population-based study

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