2023
DOI: 10.3164/jcbn.23-28
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Induction of <i>MYCN</i>-amplified neuro­blastoma differentiation through NMYC suppression using PPAR-γ antagonist

Abstract: Neuroblastomas are the most common extracranial solid tumors in children and have a unique feature of neuronal differentiation. Peroxisome proliferator-activated receptor (PPAR)-γ is reported to have neuroprotective effects in addition to having antitumor effects in various cancers. Thus, we aimed to clarify the role of PPAR-γ agonist and antagonist in malignant neuroblastomas, which also possess neuronal features. In MYCN -amplified neuroblastoma CHP212 cells, treatment with the PPAR-γ … Show more

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