Induction of LTD but not LTP through metabotropic glutamate receptors in visual cortex

Haruta, Hiroyuki; Kamishita, T.; Tp, Hicks; Mp, Takahashi; Tsumoto, Tadaharu

doi:10.1097/00001756-199409080-00036

Cited by 43 publications

(35 citation statements)

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“…In that case, antagonism of mGluRs might not block the induction of LTD. Indeed, some of the discrepancies concerning effects of mGluR antagonists on LTD (Haruta et al, 1994;Selig et al, 1995;Huber et al, 1998;Sawtell et al, 1999) may relate to differing levels of endogenous acetylcholine and norepinephrine.…”

Section: Discussionmentioning

confidence: 99%

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Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Choi¹,

Chang²,

Jiang³

et al. 2005

J. Neurosci.

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Long-term depression (LTD) in sensory cortices depends on the activation of NMDA receptors. Here, we report that in visual cortical slices, the induction of LTD (but not long-term potentiation) also requires the activation of receptors coupled to the phospholipase C (PLC) pathway. Using immunolesions in combination with agonists and antagonists, we selectively manipulated the activation of ␣1 adrenergic, M1 muscarinic, and mGluR5 glutamatergic receptors. Inactivation of these PLC-coupled receptors prevents the induction of LTD, but only when the three receptors were inactivated together. LTD is fully restored by activating any one of them or by supplying intracellular D-myo-inositol-1,4,5-triphosphate (IP 3 ). LTD was also impaired by intracellular application of PLC or IP 3 receptor blockers, and it was absent in mice lacking PLC␤1, the predominant PLC isoform in the forebrain. We propose that visual cortical LTD requires a minimum of PLC activity that can be supplied independently by at least three neurotransmitter systems. This essential requirement places PLC-linked receptors in a unique position to control the induction of LTD and provides a mechanism for gating visual cortical plasticity via extra-retinal inputs in the intact organism.

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Section: Discussionmentioning

confidence: 99%

“…The role of NMDARs in LTD in the supragranular layers of sensory cortices is well established (Kirkwood and Bear, 1994;Castro-Alamancos et al, 1995;Allen et al, 2003;Rao and Daw, 2004), whereas the possible involvement of mGluRs is still debated (Haruta et al, 1994;Huber et al, 1998;Sawtell et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Choi¹,

Chang²,

Jiang³

et al. 2005

J. Neurosci.

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“…We used LFS of layer IV for inducing LTD in AC slices because it is used for inducing LTD in the visual cortex (Artola et al 1990;Kirkwood et al 1993;Haruta et al 1994). The postsynaptic potentials were depressed by LFS, while the early component was unchanged (Fig.…”

Section: Ltd In Supragranular Field Potentialsmentioning

confidence: 99%

“…The cellular mechanisms for the neural plasticity may be explained by long-term potentiation (LTP) in the AC (Kudoh and Shibuki 1994, 1997Seki et al 1999Seki et al , 2001). However, long-term depression (LTD), as well as LTP, is suggested to play important roles in the neocortex (Artola et al 1990;Haruta et al 1994;Kimura et al 1990;Kirkwood et al 1993;Sermasi et al 1999). Because LTD has not been studied in the AC, we investigated LTD in slices obtained from the AC.…”

Section: Introductionmentioning

confidence: 99%

“…In the cerebral cortex, the LTD induced by low-frequency stimulation (LFS) is dependent on NMDARs (Kirkwood and Bear 1994;Sawtell et al 1999). It is also dependent on mGluRs (Haruta et al 1994) and induced by application of an agonist of mGluRs (Kato 1993). Therefore multiple mechanisms for increasing [Ca 2ϩ ] i appear to play a role in the induction of LTD, and the mechanisms for inducing LTD or LTP may be different among various types of synapses.…”

Section: Introductionmentioning

confidence: 99%

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Differential Dependence of LTD on Glutamate Receptors in the Auditory Cortical Synapses of Cortical and Thalamic Inputs

Kudoh

Sakai

Shibuki

2002

Journal of Neurophysiology

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Kudoh, Masaharu, Masashi Sakai, and Katsuei Shibuki. Differential dependence of LTD on glutamate receptors in the auditory cortical synapses of cortical and thalamic inputs. J Neurophysiol 88: 3167-3174, 2002. 10.1152/jn.00928.2001. Pyramidal neurons in the auditory cortex (AC) receive glutamatergic inputs from the medial geniculate body (MGB inputs) and other pyramidal neurons (pyramidal inputs). We found that the induction of long-term depression (LTD) in supragranular layers was only partially suppressed by 50 M D-(Ϫ)-2-amino-5-phosphonovalerate (APV), an antagonist of Nmethyl-D-aspartate (NMDA) receptors (NMDARs), and 500 M (ϩ)-␣-methyl-4-carboxyphenylglycine (MCPG), an antagonist of metabotropic glutamate receptors (mGluRs). However, LTD was not observed in the mixture of APV and MCPG. We hypothesized that the mixed dependence of LTD on glutamate receptors could be attributed to the heterogeneity of MGB inputs and pyramidal inputs. To test this hypothesis, the angle of slicing and other recording conditions were adjusted so that postsynaptic potentials were recorded in normal slices, but not in the slices prepared from the rats with MGB lesion. In these experiments, LTD was suppressed by MCPG alone. The conditions were adjusted to minimize the contribution of MGB inputs in field potentials. In these experiments, the induction of LTD was suppressed by APV alone. Interestingly, the induction of LTD was partially suppressed by 20 M nifedipine, a blocker of L-type Ca 2ϩ channels, in the slices prepared from the rats with MGB lesions, but not in normal slices. These findings suggest that the induction of LTD requires activation of mGluRs in the synapses of MGB inputs and of NMDARs in the synapses of pyramidal inputs.

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Developmental and sensory-dependent changes of phosphoinositide-linked metabotropic glutamate receptors

et al. 1997

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Metabotropic glutamate receptors (mGluRs) can modulate synaptic transmission, and there is evidence that phosphoinositide (PI)-linked mGluRs may be involved in sensory-dependent plasticity during the development of cat visual cortex. Consequently, we asked the questions: Where are the PI-linked mGluRs (mGluR1alpha and mGluR5) in the visual cortex? Does the quantity and distribution of these receptors change in the cat visual cortex during postnatal development, and are these features sensory-dependent? We found that the quantity of mGluR1alpha decreases with age, whereas the laminar distribution of mGluR1alpha remains the same. Quantity of mGluR5 also decreases, but the laminar distribution of mGluR5 changes during development. The pattern and timing of the mGluR5 change in distribution follow the development of geniculocortical afferents. Immunostaining indicates that reduction of receptor occurs mainly in layers V-VI for mGluR1alpha and outside layer IV for mGluR5. Dark-rearing postpones the laminar change of mGluR5 and produces an increased level of mGluR5 between postnatal 1.5-6 weeks of age but has no significant effect on the mGluR1alpha distribution or the mGluR1alpha quantity. These results suggest that mGluR1alpha and mGluR5 are involved in different aspects of cortical development. The mGluR5 is more likely to be involved in sensory-dependent events than mGluR1alpha. The lack of developmental correlation between mGluR quantities and the critical period for ocular dominance plasticity also suggests that other factors besides mGluR quantities are important for ocular dominance plasticity.

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Induction of LTD but not LTP through metabotropic glutamate receptors in visual cortex

Cited by 43 publications

References 0 publications

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Multiple Receptors Coupled to Phospholipase C Gate Long-Term Depression in Visual Cortex

Differential Dependence of LTD on Glutamate Receptors in the Auditory Cortical Synapses of Cortical and Thalamic Inputs

Developmental and sensory-dependent changes of phosphoinositide-linked metabotropic glutamate receptors

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