Induction of mast cell accumulation by chymase via an enzymatic activity‐ and intercellular adhesion molecule‐1‐dependent mechanism

Abstract

The finding that mast cells accumulate in response to chymase implies further that chymase is a major pro-inflammatory mediator of mast cells. This effect of chymase, a major product of mast cell granules, suggests a novel self-amplification mechanism for mast cell accumulation in allergic inflammation. Mast cell stabilizers and inhibitors of chymase may have potential as a treatment of allergic disorders.

Protease profile of normal and neoplastic mast cells in the human bone marrow with special emphasis on systemic mastocytosis

“…In addition to the function of angiotensin II as an effector peptide of the renin-angiotensin system, it also has effects on the regulation of cell growth, angiogenesis, regeneration, and tissue remodeling (Atiakshin et al 2020 ; Dong et al 2013 ). Chymase is capable of causing MC migration to the place of destination in tissues and thus acts as an inducer of directional movement (Zhang et al 2018 ). Our previous studies convincingly indicated MCs direct participation in fibrillogenesis using a pronounced inductive effect on the ratio of the tissue microenvironment components, including areas around the fibroblastic differone cell (Atiakshin et al 2020 ).…”

Protective effects of rabbit sacculus-derived antimicrobial peptides on SPF chicken against infection with very virulent infectious bursal disease virus

“…Interestingly, careful observations showed that tryptase expression had a positive correlation with mast cell populations during vvIBDV infection. Some previous studies have demonstrated that tryptase released from the activated mast cells may act as an amplification signal for mast cell activation and the release of some mediators ( He et al, 1998 ; Zhang et al, 2018 ). Comparison of results from inspection between vvIBDV-infection and RSRP-treated chickens, suggests that administration of RSRP directly or indirectly (in vitro mix and then inoculation) may play its protective effects via reducing the tryptase expression.…”

Insights into Early-Pregnancy Mechanisms: Mast Cells and Chymase CMA1 Shape the Phenotype and Modulate the Functionality of Human Trophoblast Cells, Vascular Smooth-Muscle Cells and Endothelial Cells

“…To the best of our knowledge, no studies studied the effect of chymases on EVT migration. Nevertheless, there are numerous studies showing that chymase is a potent chemoattractant for cells other than EVTs, namely eosinophils [ 71 ], monocytes and neutrophils [ 72 ], and even MCs, presenting a self-amplification mechanism for MC accumulation [ 73 ]. However, inhibition of migration was also shown for epithelial cells [ 74 ] and neutrophils [ 75 ].…”