Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Harvima, Ilkka T.

doi:10.1038/jid.2008.331

Cited by 20 publications

(18 citation statements)

References 11 publications

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“…Breakdown of the ECM must occur for tumors to become mobile and relocate themselves. In keratinocytes, histamine increases the expression of MMP‐9 by way of the H1HR38 and contributes to the active migratory potential through the basement membrane 39. A correlation between MMPs and pancreatic cancer has been demonstrated and in this study histamine, by way of H1 and H2 HRs, increased the tumoral progression of pancreatic cancer 26.…”

Section: Discussionsupporting

confidence: 56%

The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis

et al. 2011

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Cholangiocarcinoma (CCA) is a biliary cancer arising from damaged bile ducts. Epithelialmesenchymal transition (EMT) occurs as epithelial cells begin to resemble mesenchymal cells leading to increased invasion potential as the extracellular matrix (ECM) degrades. Histamine exerts its effects by way of four receptors (H1-H4 HRs). Clobenpropit, a potent H4HR agonist, inhibits mammary adenocarcinoma growth. We have shown that (1) cholangiocytes and CCA cells express H1-H4 HRs and (2) the H3HR decreases CCA proliferation. We evaluated the effects of clobenpropit on CCA proliferation, invasion, EMT phenotypes, and ECM degradation. In vitro, we used CCA cell lines to study proliferation, signaling pathways, and the morphological invasive potential. Gene and protein expression of the hepatobiliary epithelial markers CK-7, CK-8, and CK-19, the focal contact protein paxillin, and the mesenchymal markers fibronectin, s100A4, and vimentin were evaluated. Cell invasion across an ECM layer was quantitated and matrix metalloproteinase-1, -2, -3, -9, and -11 gene and protein expression was examined. Evaluation of the specific role of H4HR was performed by genetic knockdown of the H3HR and overexpression of H4HR. Proliferation was evaluated by proliferating cellular nuclear antigen immunoblotting. In vivo, xenograft tumors were treated with either vehicle or clobenpropit for 39 days. Tumor volume was recorded every other day. Clobenpropit significantly decreased CCA proliferation by way of a Ca 21 -dependent pathway and altered morphological development and invasion. Loss of H3HR expression or overexpression of H4HR significantly decreased CCA proliferation. In vivo, clobenpropit inhibited xenograft tumor growth compared with controls. Conclusion: Modulation of H4HR by clobenpropit disrupts EMT processes, ECM breakdown, and invasion potential and decreases tumor growth. Interruption of tumorigenesis and invasion by histamine may add to therapeutic advances for CCAs.

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Section: Discussionsupporting

confidence: 56%

The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis

et al. 2011

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“…Histamine concentration in MC secretory granules can be up to 100 mmol L −1 . Mastocytosis has been reported in OLP where degranulated MCs are considered the plausible source of ‘burst‐released’ histamine towards BM and oral epithelium .…”

Section: Discussionsupporting

confidence: 49%

“…Histamine concentration in MC secretory granules can be up to 100 mmol L À1 . 33 Mastocytosis has been reported in OLP where degranulated MCs are considered the plausible source of 'burst-released' histamine towards BM and oral epithelium. 15 Our results indicate a negative-feedback effect of micromolar histamine on HDC expression in HOKs, and yet HDC was increased in OLP.…”

Section: Discussionmentioning

confidence: 99%

Histamine metabolism and transport are deranged in human keratinocytes in oral lichen planus

et al. 2017

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“…During inflammation, immune cells, mainly neutrophils, can effectively infiltrate into the dermal layer. Keratinocytes, mast cells and infiltrated neutrophils in skin have been reported to secrete MMP-9 for tissue remodeling in response to inflammation [34-36]. MMP-9 has further been reported to be directly mechanistically involved in the increases of vascular permeability [37-39].…”

Section: Discussionmentioning

confidence: 99%

Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin

et al. 2011

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BackgroundSkin is the largest organ in the body, and is directly exposed to extrinsic assaults. As such, the skin plays a central role in host defense and the cutaneous immune system is able to elicit specific local inflammatory and systemic immune responses against harmful stimuli. 12-O-tetradecanoylphorbol-13-acetate (TPA) can stimulate acute and chronic inflammation and tumor promotion in skin. TPA-induced dermatitis is thus a useful in vivo pharmacological platform for drug discovery. In this study, the inhibitory effect of briarane-type diterpenes (BrDs) from marine coral Briareum excavatum on TPA-induced dermatitis and dendritic cell (DC) function was explored.MethodsEvans blue dye exudation was used to determine vascular permeability. H&E-stained skin section was used to determine the formation of edema in mouse abdominal skin. We also used immunohistochemistry staining and western blot assays to evaluate the activation of specific inflammation makers and key mediators of signaling pathway in the mouse skin. Furthermore, mouse bone marrow DCs were used to determine the relationship between the chemical structure of BrDs and their regulation of DC function.ResultsBrD1 remarkably suppressed TPA-induced vascular permeability and edema in skin. At the biochemical level, BrD1 inhibited TPA-induced expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase-9, the key indicators of cutaneous inflammation. This inhibition was apparently mediated by interference with the Akt/NF-κB-mediated signaling network. BrD1 also inhibited TNF-α and IL-6 expression in LPS-stimulated BMDCs. The 8, 17-epoxide of BrDs played a crucial role in the inhibition of IL-6 expression, and replacement of the C-12 hydroxyl group with longer esters in BrDs gradually decreased this inhibitory activity.ConclusionsOur results suggest that BrDs warrant further investigation as natural immunomodulatory agents for control of inflammatory skin diseases.

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Induction of Matrix Metalloproteinase-9 in Keratinocytes by Histamine

Cited by 20 publications

References 11 publications

The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis

The H4 histamine receptor agonist, clobenpropit, suppresses human cholangiocarcinoma progression by disruption of epithelial mesenchymal transition and tumor metastasis

Histamine metabolism and transport are deranged in human keratinocytes in oral lichen planus

Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin

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