Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by<i>Angiostrongylus cantonensis</i>

Lai, Shih‐Chan; Twu, J.J.; Jiang, Shinn‐Jong; Hsu, Jeng-Dong; Chen, K.M.; Chiaing, H.C.; Wang, C.J.; Tseng, C. K.; Shyu, Ling-Yuh; Lee, H.H.

doi:10.1179/000349804225021479

Cited by 26 publications

(19 citation statements)

References 30 publications

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“…thalidomide [94]. Matrix metalloproteinases play a critical role in CNS inflammation [83,95] and their inhibition reduced the severity of NA lesions in mice [96,97]. A number of drugs, including doxycycline and albendazole, inhibit metalloproteinases and such agents may be useful in treating NA [90,96].…”

Section: Discussionmentioning

confidence: 99%

Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature

Lee

Smaller

et al. 2012

Parasites Vectors

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Cases of canine neural angiostrongylosis (NA) with cerebrospinal fluid (CSF) evaluations in the peer-reviewed literature were tabulated. All cases were from Australia. A retrospective cohort of 59 dogs was contrasted with a series of 22 new cases where NA was diagnosed by the presence of both eosinophilic pleocytosis and anti- Angiostrongylus cantonensis immunloglobulins (IgG) in CSF, determined by ELISA or Western blot. Both cohorts were drawn from south east Queensland and Sydney. The retrospective cohort comprised mostly pups presented for hind limb weakness with hyperaesthesia, a mixture of upper motor neurone (UMN) and lower motor neurone (LMN) signs in the hind limbs and urinary incontinence. Signs were attributed to larval migration through peripheral nerves, nerve roots, spinal cord and brain associated with an ascending eosinophilic meningo-encephomyelitis. The contemporary cohort consisted of a mixture of pups, young adult and mature dogs, with a wider range of signs including (i) paraparesis/proprioceptive ataxia (ii) lumbar and tail base hyperaesthesia, (iii) multi-focal central nervous system dysfunction, or (iv) focal disease with neck pain, cranial neuropathy and altered mentation. Cases were seen throughout the year, most between April and July (inclusive). There was a preponderance of large breeds. Often littermates, or multiple animals from the same kennel, were affected simultaneously or sequentially. A presumptive diagnosis was based on consistent signs, proximity to rats, ingestion/chewing of slugs or snails and eosinophilic pleocytosis. NA was diagnosed by demonstrating anti- A. cantonensis IgG in CSF. Detecting anti- A. cantonensis IgG in serum was unhelpful because many normal dogs (20/21 pound dogs; 8/22 of a hospital population) had such antibodies, often at substantial titres. Most NA cases in the contemporary series (19/22) and many pups (16/38) in the retrospective cohort were managed successfully using high doses of prednisolone and opioids. Treatment often included antibiotics administered in case protozoan encephalomyelitis or translocated bacterial meningitis was present. Supportive measures included bladder care and physiotherapy. Several dogs were left with permanent neural deficits. Dogs are an important sentinel species for NA. Human cases and numerous cases in tawny frogmouths were reported from the same regions as affected dogs over the study period. Electronic supplementary material The online version of this article (doi:10.1186/1756-3305-5-70) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature

Lee

Smaller

et al. 2012

Parasites Vectors

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“…Samples were centrifugated at 12,000 g for 10 min to remove debris. The protein was analysed using the method of Lai et al. (2004).…”

Section: Methodsmentioning

confidence: 99%

Matrix metalloproteinase‐2, ‐9 and ‐13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis

Hsu

Lai

2007

Int J Experimental Path

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Summary Pulmonary granuloma formation and fibrosis were experimentally induced in Sprague–Dawley strain rats by Angiostrongylus cantonensis. Increased protein levels of matrix metalloproteinase (MMP)‐2, ‐9, ‐13 and the imbalance between these enzymes and metalloproteinase inhibitors, tissue inhibitors of MMPs (TIMP‐1 and ‐2), occur during granulomatous fibrosis. Activation of proteolytic enzymes (MMP‐2, ‐9 and ‐13) and fibronectin degradation occur simultaneously. Furthermore, the present study demonstrated that fibronectin avidly binds MMP‐2, ‐9 or ‐13. Immunohistochemical observations also showed the localization of MMP‐13, TIMP‐1 and ‐2 within the infiltrating leucocytes. These results suggest that MMP‐2, ‐9 and ‐13 may participate in the fibronectin degradation of A. cantonensis‐induced granulomatous fibrosis.

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“…MMP-9 is detected in the CSF of patients with HTLV-1-induced neurological disease [49]. Astrocytes stimulated by HTLV-1-activated CD4 + T lymphocytes secrete increased MMP-3 and MMP-9, mediated through both soluble factor and integrin- [111,112] dependent pathways [50]. Increased MMP-9 expression is demonstrated in neural cells in the perivascular space in biopsies from patients with HTLV-1 infection and neurological disease, implicating MMP-9 in the local breakdown of the blood-brain barrier [50].…”

Section: Human T Lymphotrophic Virus (Htlv-1)mentioning

confidence: 99%

The paradox of matrix metalloproteinases in infectious disease

Elkington

O'Kane

Friedland

2005

Clinical and Experimental Immunology

284

227

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SummaryMatrix metalloproteinases (MMPs) are a family of proteolytic enzymes that perform multiple roles in the normal immune response to infection. MMPs facilitate leucocyte recruitment, cytokine and chemokine processing, defensin activation and matrix remodelling. However, excess MMP activity following infection may lead to immunopathology that causes host morbidity or mortality and favours pathogen dissemination or persistence. Here, we review the normal functions of MMPs in immunity and then discuss viral and bacterial infections where excess MMP activity has been implicated in pathology, specifically examining HIV, HTLV-1, hepatitis B, endotoxin shock, Helicobacter pylori and Mycobacterium tuberculosis . Tissue destruction may be exacerbated further by bacterial-derived enzymes which activate the host proMMPs. Finally, the potential for therapeutic targeting of excess MMP activity in infection is considered.

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Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused byAngiostrongylus cantonensis

Cited by 26 publications

References 30 publications

Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature

Twenty two cases of canine neural angiostrongylosis in eastern Australia (2002-2005) and a review of the literature

Matrix metalloproteinase‐2, ‐9 and ‐13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis

The paradox of matrix metalloproteinases in infectious disease

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