Induction of Metabolic Reprogramming in Kidney by Singlet Diradical Nanoparticles

Abstract

Polycyclic aromatic compounds with an open‐shell singlet diradical ground state, namely singlet diradicals, have recently gained attention in the fields of organic electronics, photovoltaics, and spintronics owing to their unique electronic structures and properties. Notably, singlet diradicals exhibit tunable redox amphoterism, which makes them excellent redox‐active materials for biomedical applications. However, the safety and therapeutic efficacy of singlet diradicals in biological systems have not yet been explored. Herein, the study presents a newly designed singlet diradical nanomaterial, diphenyl‐substituted biolympicenylidene (BO‐Ph), exhibiting low cytotoxicity in vitro, non‐significant acute nephrotoxicity in vivo, and the ability to induce metabolic reprogramming in kidney organoids. Integrated transcriptome and metabolome analyses reveal that the metabolism of BO‐Ph stimulates glutathione (GSH) synthesis and fatty acid degradation, increases the levels of intermediates in the tricarboxylic acid (TCA) and carnitine cycles, and eventually boosts oxidative phosphorylation (OXPHOS) under redox homeostasis. Benefits of BO‐Ph‐induce metabolic reprogramming in kidney organoids include enhancing cellular antioxidant capacity and promoting mitochondrial function. The results of this study can facilitate the application of singlet diradical materials in the treatment of clinical conditions induced by mitochondrial abnormalities in kidney.

Solution‐processed D‐A‐π‐A‐D radicals for highly efficient photothermal conversion

“…The merits of simple synthesis and no ionic toxicity highlight the potential of radical systems, which laid a foundation for the application of organic small molecule photothermal materials to seawater evaporation and photothermal therapy. [ 61–66 ]…”

Sulfone-Functionalized Chichibabin’s Hydrocarbons: Stable Diradicaloids with Symmetry Breaking Charge Transfer Contributing to NIR Emission beyond 900 nm

“…Since the pioneering report of the earliest isolable yet highly air-sensitive diradicaloid species called Thiele’s and Chichibabin’s hydrocarbons in the 1900s, organic π-delocalized diradicaloids have fascinated chemists for more than one century. − With their unique open-shell electronic structures, these materials not only hold a significant importance in fundamental chemistry but also exhibit tremendous intriguing physicochemical properties such as intensive low-energy absorption, amphoteric redox behaviors, unique π-magnetisms, and so on. − Therefore, although the stability issue still remains as a major obstacle hampering their future uses, a great number of structurally diverse diradicaloids with relatively long lifetimes under inert environment and even in ambient conditions have been successfully prepared (especially in the past two decades), − demonstrating great potentials for a wide range of applications such as ambipolar organic field-effect transistors (OFETs), organic spintronics, near-infrared (NIR) dyes, batteries, and so on. − …”