Induction of Mitochondrial-Mediated Apoptosis by Morinda Citrifolia (Noni) in Human Cervical Cancer Cells

Roles of Plant Extracts and Constituents in Cervical Cancer Therapy

“…All have been found to be potent cytotoxic and apoptosis agent in HeLa and SiHa cell lines (Gupta et al, 2013). It was reported in this study that the potency of cisplatin (CP, 10 μg/ml), the commercially available anticancer drug in combination with Noni (N, 10%, v/v) (N+CP) was enhanced significantly in these two cancer cells after 24 h of incubation.…”

“…Cervical cancer is a major health problem worldwide and is the most frequent cause of cancer in women in India (Jemal et al, 2011;Pathak et al, 2012;Gupta et al, 2013). Early detection and an affordable drug with clinical efficacies have to go hand-in-hand in order to comprehensibly address this serious health challenge.…”

Cytotoxic Effects of Phytophenolics from Caesalpinia mimosoides Lamk on Cervical Carcinoma Cell Lines through an Apoptotic Pathway

“…Liu et al (2006a) reported that both HeLa and SiHa cells are highly radioresistant and chemoresistant compared to other cervical cancer cell lines, but the present study indicated that the HeLa cell line was the most sensitive to multiple phytochemicals. However, It was also reported that the potency of cisplatin in combination with Noni were more in SiHa cells as compared to HeLa cells (Gupta et al, 2013).…”

Flavonoids from Orostachys Japonicus A. Berger Induces Caspase-dependent Apoptosis at Least Partly through Activation of p38 MAPK Pathway in U937 Human Leukemic Cells

“…This finding was confirmed by caspase activity assay. Many well-known phytochemicals that can safely modulate physiological function and enhance anti-cancer activity induce apoptosis through mitochondrial pathway (Chun et al, 2003;Gupta et al, 2013). Similarly, FEOJ induced apoptosis through induction of loss of MMP (ΔΨm).…”