Induction of mucosal HIV-specific B and T cell responses after oral immunization with live coxsackievirus B4 recombinants

Gu, Rui; Stagnar, Cristy; Zaichenko, Lesya; Ramsingh, Arlene I.

doi:10.1016/j.vaccine.2012.03.034

Cited by 4 publications

References 53 publications

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The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Liu

et al. 2018

Protein &Amp; Cell

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A human immunodeficiency virus type-1 (HIV-1) vaccine which is able to effectively prevent infection would be the most powerful method of extinguishing pandemic of the acquired immunodeficiency syndrome (AIDS). Yet, achieving such vaccine remains great challenges. The membrane-proximal external region (MPER) is a highly conserved region of the envelope glycoprotein (Env) gp41 subunit near the viral envelope surface, and it plays a key role in membrane fusion. It is also the target of some reported broadly neutralizing antibodies (bNAbs). Thus, MPER is deemed to be one of the most attractive vaccine targets. However, no one can induce these bNAbs by immunization with immunogens containing the MPER sequence(s). The few attempts at developing a vaccine have only resulted in the induction of neutralizing antibodies with quite low potency and limited breadth. Thus far, vaccine failure can be attributed to various characteristics of MPER, such as those involving structure and immunology; therefore, we will focus on these and review the recent progress in the field from the following perspectives: (1) MPER structure and its role in membrane fusion, (2) the epitopes and neutralization mechanisms of MPER-specific bNAbs, as well as the limitations in eliciting neutralizing antibodies, and (3) different strategies for MPER vaccine design and current harvests.

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The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Liu

et al. 2018

Protein &Amp; Cell

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Replication-Competent Viral Vectors for Vaccine Delivery

Parks

2017

Human Vaccines

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Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington′s disease

et al. 2015

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Immunotherapy, both active and passive, is increasingly recognized as a powerful approach to a wide range of diseases, including Alzheimer's and Parkinson's. Huntington's disease (HD), an autosomal dominant disorder triggered by misfolding of huntingtin (HTT) protein with an expanded polyglutamine tract, could also benefit from this approach. Individuals can be identified genetically at the earliest stages of disease, and there may be particular benefits to a therapy that can target peripheral tissues in addition to brain. In this active vaccination study, we first examined safety and immunogenicity for a broad series of peptide, protein and DNA plasmid immunization protocols, using fragment (R6/1), and knock-in (zQ175) models. No safety issues were found. The strongest and most uniform immune response was to a combination of three non-overlapping HTT Exon1 coded peptides, conjugated to KLH, delivered with alum adjuvant. An N586-82Q plasmid, delivered via gene gun, also showed ELISA responses, mainly in the zQ175 strain, but with more variability, and less robust responses in HD compared with wild-type controls. Transcriptome profiling of spleens from the triple peptide-immunized cohort showed substantial HD-specific differences including differential activation of genes associated with innate immune responses, absence of negative feedback control of gene expression by regulators, a temporal dysregulation of innate immune responses and transcriptional repression of genes associated with memory T cell responses. These studies highlight critical issues for immunotherapy and HD disease management in general.

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Induction of mucosal HIV-specific B and T cell responses after oral immunization with live coxsackievirus B4 recombinants

Cited by 4 publications

References 53 publications

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Replication-Competent Viral Vectors for Vaccine Delivery

Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington′s disease

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