Induction of multicomponent peptide assembly via solvent exchange strategy for enhanced structure and bioactivities

Li, Yajuan; McClements, David Julian; Pan, Fei; Tian, Longjiang; Li, Shanglin; Zhang, Xin; Liu, Jingbo; Zhang, Ting; Du, Zhiyang

doi:10.1016/j.cej.2024.157484

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.157484

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Induction of multicomponent peptide assembly via solvent exchange strategy for enhanced structure and bioactivities

Yajuan Li,

David Julian McClements,

Fei Pan

et al.

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Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers

Tian,

You,

Liu

et al. 2024

J. Agric. Food Chem.

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The fusion assembly strategy of supramolecular chemistry combined with dynamic covalent chemistry has provided novel insights into the design of precision nutrition and intelligent drug delivery carriers. This work involved the development of a supramolecular self-assembly originating from entropy-and enthalpy-driven dynamic covalent bonding on Schiff bases between egg white-derived peptide Gln-Ile-Gly-Leu-Phe (QIGLF) and glutaraldehyde (GA), denoted QIGLF−GA. The assembly exhibited outstanding assembly characteristics and multiwavelength autofluorescence properties. Benefiting from the potent facilitation of the dynamic covalent interaction of Schiff base on the noncovalent assembly force network, QIGLF−GA was afforded an encapsulation capacity of curcumin (Cur) of more than 22% (≫ 10%) and rationally inhibited P-glycoprotein-mediated cellular efflux and markedly elevated the efficacy of Cur in overcoming the intestinal epithelial absorption barrier to the circulation with the help of endocytosis. Furthermore, QIGLF−GA-Cur features responsive release under weakly acidic conditions, which dramatically contributes to the intracellular bioavailability of Cur.

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Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers

Tian,

You,

Liu

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

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Induction of multicomponent peptide assembly via solvent exchange strategy for enhanced structure and bioactivities

Cited by 1 publication

References 53 publications

Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers

Schiff Base Mediated Food-Derived Peptide Supramolecular Self-Assembly as Curcumin Carriers

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