Induction of Murine B Cell Proliferation and Immunoglobulin Synthesis by Some Bacterial Ribosomes

Abstract

Ribosomal preparations from Klebsiella pneumoniae, Haemophilus influenzae,

Prevention of Recurrent Respiratory Tract Infections in Children Using a Ribosomal Immunotherapeutic Agent

“…ing immune responses: polyclonal stimulation of B lymphoThe most important publication reviewed, both in terms of cytes [34,35] and T lymphocytes; [35] activation of polymorphonuclear numbers of patients and quality of evidence, was prepared by cells, [36][37][38][39][40] dendritic cells, [41] and macrophages through phagocytoBellanti et al [49] This consisted of a review of the international sis; [42] production of cytokines; [43][44][45][46] and stimulation of natural Ribomunyl ® registration clinical file, which includes all the required evaluations of the product and is submitted to the authorikiller cells [35,47,48] inducing production of interferon-γ [48] and ties in different countries responsible for official registration and class 1 (viral) interferon. [49] legal market authorization of the product.…”

“…[29][30][31][32] Indeed, oral administration of Ribomunyl ® has lant preparations (e.g. Biostim ® , Broncho-Vaxom ® , Luivac ® , IRS been shown to stimulate the mucosal immune system; [29,[32][33][34] for 19 ® , and Ribomunyl ® ) 1 are marketed in the world for the prevenexample, an increase in specific antibody-forming cells in periphtion and/or treatment of bacterial infections of the upper and/or eral blood and in tonsils, [29,30] and a higher level of specific salivary IgA in saliva have been observed. [32] Furthermore, non-…”

Ribosomal immune stimulation. The review of trials evaluating clinical significance of the point in prevention of upper and lower respiratory tract infections in adults and children

“…Обзор исследований, оценивающих ее клиническую значимость в предотвращении инфекций верхних и нижних дыхательных путей у взрослых и детей были продемонстрированы в случае поликлональ ной стимуляции В [32,33] и Т лимфоцитов [34], активизации полиморфноядерных клеток [35][36][37][38][39], а также макрофагов через фагоцитоз [40], образова нии цитокинов [41][42][43] и стимуляции натуральных клеток киллеров [44]. Таким образом, благодаря своему составу Рибомунил ® имеет двойной меха низм действия, обеспечивающий профилактику как бактериальных, так и вирусных инфекций [24].…”

“…Было продемонст рировано, что рибосомальный иммуностимулятор вызывает у людей выработку гуморальных и секре торных специфических антител против 4 бактери альных возбудителей, входящих в состав препарата [28,30]. При пероральном приеме Рибомунил ® сти мулирует секреторную иммунную систему [24,31,32]. Более того, адьювантные иммуностимулиру ющие свойства мембранной фракции K. pneumoniae Джозеф А. Белланти 1 , Дарио Оливьери 2 , Эли Серрано 3…”

Use of Bacterial Ribosomal Immunostimulators in Respiratory Tract Infections

“…Both antibodies and activated T cells have been identified after treatment with ribosomal immunostimulators, and react against the ribosomal preparation administered as well as against whole bacterial extracts. 19,40,57,65,66] Lynn et al [41] and Gregory et aI.l5] moreover demonstrated that naturally occurring antibodies, i.e. those triggered by a pre-vious contact with wild-type bacteria, reacted either with whole bacteria or with ribosomal preparations.…”