Induction of Neoplasms by Viruses in Marmoset Monkeys

Deinhardt, F; Wolfe, Lauren G.; Northrop, Robert L.; Marczynska, Barbara; Ogden, James; McDonald, Ruth; Falk, Lawrence A.; Shramek, Grace; Smith, RG; Deinhardt, Jean

doi:10.1159/000460360

Cited by 40 publications

(11 citation statements)

References 33 publications

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“…On the other hand, the disease in one out of three animals following closely on the inoculation of EB virus and the presence of the virus in cultured cells from the lesions, parallels the findings with herpesvirus saimiri and its lymphoma (Melendez et a[., 19696;Deinhardt et al, 1972) and is reminiscent of the situation with EB virus and Burkitt's lymphoma (Epjtein and Achong, 1973). But at this stage it cannot be determined whether the EB virus was present in the cultured monkey lymphoid cells because its genome had malignantly transformed them in vivo and had then been activated to a productive infection when the cells were cultured, or whether the genome was present and unexpressed in some less interesting form of infection (see Epstein and Achong, 1973).…”

Section: Figure 14supporting

confidence: 66%

Pilot experiments with EB virus in owl monkeys (aotus trivirgatus). II. EB virus in a cell line from an animal with reticuloproliferative disease

Epstein

Rabin²,

Ball

et al. 1973

Intl Journal of Cancer

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A continuous cell line has been established in culture from a pathological lymph node of an owl monkey with reticuloproliferative disease after inoculation with E B virus. The cells grow in suspension in clumps or as single individuals and show the characteristic features of lymphoblasts with some differentiation to reticulum cells; their karyotype is typical of one sub-species of owl monkey. A herpes virus has been found in the cells and has been identified as E B virus in two types of immunofluorescence test using two different specific antisera; this identification was confirmed by the ability of the virus to transform normal human cord-blood lymphocytes and make them grow as

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Section: Figure 14supporting

confidence: 66%

Pilot experiments with EB virus in owl monkeys (aotus trivirgatus). II. EB virus in a cell line from an animal with reticuloproliferative disease

Epstein

Rabin²,

Ball

et al. 1973

Intl Journal of Cancer

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“…The cellular tropism of SSV is in accordance with this idea; in vivo, SSV can induce sarcomas and even gliomas-i.e., tumors derived from cells that bear PDGF receptors (38,39).…”

Section: Discussionmentioning

confidence: 99%

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

Johnsson¹,

Betsholtz²,

Helm³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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We have compared the functional properties of a growth factor partially purified from medium conditioned by simian sarcoma virus-transformed cells with those of platelet-derived growth factor (PDGF). The factor mimicked the effects induced by PDGF: it bound to and activated human fibroblast PDGF receptors and stimulated DNA synthesis.These activities were specifically inhibited by PDGF antibodies and thus elicited by a factor(s) immunologically related to PDGF. The factor behaved as a secretory protein, since about 95% of the receptor-binding activity was found in the medium after a 48-hr serum-free incubation. Structural characteriza-

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“…A spontaneously occurring lymphosarcoma of reticulum cell-type was reported in a wildcaught cotton-top tamarin [23]. It has long been known that lymphomas can be experimentally induced in this species by infection with Herpes6irus (H.) saimiri [5,13,31,32], Epstein -Barr virus (EBV) [11,21,28] and H. ateles [9]. Recently, an Epstein -Barr-related herpesvirus was isolated from spontaneous B-cell lymphomas in common marmosets, suggesting that oncogenic herpesviruses are not only endemic in Old World primates but also in New World species [4,25].…”

Section: Introductionmentioning

confidence: 99%

Three spontaneous lymphomas in a colony of cotton‐top tamarins (Saguinus oedipus)

Hofmann

Kahnt

Mätz‐Rensing

et al. 2001

J of Medical Primatology

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Cotton-top tamarins are well known for their prevalence to idiopathic colitis and adenocarcinomas. At the same time, information on the incidence of spontaneous lymphomas in this highly endangered species is rare. Records, 212 in total, of cotton-top tamarins (Saguinus oedipus) necropsied at the German Primate Centre between 1979 and 1998 were viewed to establish the prevalence of lymphoid neoplasms. Neoplastic lymphoid cell growth was mentioned in three necropsy records. Immunohistology was performed in all three cases on the remaining formalin-fixed, paraffin-embedded tissue using antibodies against CD20, CD3, lysozyme, Ki-67, IgM, IgG, kappa, lambda and EBNA-2. Combining histological and immunohistological results, the lymphomas could be differentiated into two low-grade T-cell lymphomas and one high-grade multicentric polymorphic B-cell lymphoma. This corresponds to a 1.4% incidence of lymphomas in our cotton-top tamarin population over a period of 19 years. Although frozen material was not available and virological testing could not be carried out, clinical or histological evidence did not support an aetiological role of Herpes (H.) saimiri, H. ateles, simian T-cell leukaemia virus type 1 (STLV-1) or Epstein-Barr-related herpesvirus in any of these cases. The lymphomas were considered to be spontaneous.

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Induction of Neoplasms by Viruses in Marmoset Monkeys

Cited by 40 publications

References 33 publications

Pilot experiments with EB virus in owl monkeys (aotus trivirgatus). II. EB virus in a cell line from an animal with reticuloproliferative disease

Pilot experiments with EB virus in owl monkeys (aotus trivirgatus). II. EB virus in a cell line from an animal with reticuloproliferative disease

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

Three spontaneous lymphomas in a colony of cotton‐top tamarins (Saguinus oedipus)

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