Induction of new metabolites from the endophytic fungus Bionectria sp. through bacterial co-culture

Kamdem, Ramsay S.T.; Wang, Hao; Wafo, Pascal; Ebrahim, Weaam; Özkaya, Ferhat Can; Makhloufi, Gamall; Janiak, Christoph; Sureechatchaiyan, Parichat; Kassack, Matthias U.; Lin, Wenhan; Liu, Zhen; Proksch, Peter

doi:10.1016/j.fitote.2017.10.021

Cited by 40 publications

(28 citation statements)

References 30 publications

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“…Compounds 283-285 displayed weak to moderate activity, whereas the other metabolites had no activity [30]. Compound 100 possessed no cytotoxicity against A2780 cell line [82]. Compounds 78 and 79, isocoumarin ribonic glycosides biosynthesized by Daldinia eschscholzii, had no obvious activity (IC 50 > 40 µg/mL) towards SMMC-7721, HL-60, A-549, SW-480, and MCF-7 using the MTT assay [54].…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

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Section: Cytotoxic Activitymentioning

confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

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“…Four siderophore analogs, clonocoprogens A (26), B (27) and C (28) and N 14 -plmitoylcoprogen (29), were isolated from Clonostachys compactiuscula FKR-0021. They exhibited antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum strains, with IC50 values ranging from 1.7 μM to 9.9 μM [19].…”

Section: Piperazinesmentioning

confidence: 99%

“…through bacterial co-culture. Penicolinate A (83) exhibited potent cytotoxic activity against the human ovarian cancer cell line A2780 with an IC50 value of 4.1 μM [28].…”

Section: Other Nitrogen-containing Metabolitesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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Clonostachys (teleomorph: Bionectria) fungi are well known to produce a variety of secondary metabolites with various biological activities to show their pharmaceutical and agrochemical applications. Up to now, at least 229 secondary metabolites, mainly including 84 nitrogen-containing metabolites, 85 polyketides, 40 terpenoids, and 20 other metabolites, have been reported. Many of these compounds exhibit biological activities, such as cytotoxic, antimicrobial, antileishmanial, antimalarial activities. This mini-review aims to summarize the diversity of the secondary metabolites as well as their occurrences in Clonostachys fungi and biological activities.

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“…During the past few decades, co-culturing of either fungus and fungus or fungus and bacterium has been shown to be a method that stimulates the regulatory systems by activation of the silent biosynthesis of a broad diversity of bioactive metabolites and also enhances production of constitutive fungal compounds which are not isolated in axenic cultures in vitro (Ola et al, 2013, Liu et al, 2017Wakefield et al, 2017;Kamdem et al, 2018;Qadir et al, 2018;Tomm et al, 2019). The co-culturing of different microorganisms from various habitats has been intensively studied in many media to investigate the production of unexplored bioactive metabolites, enzymes or other constituents (Ola et al, 2013;Moussa et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of Co-culturing with Live and Autoclaved Bacillus subtilis on Antagonistic Activity of Marine Fungi against Plant Pathogens

Mokkala¹,

Dethoup²

2020

J Pure Appl Microbiol

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The co-culturing of the fungi with Bacillus subtilis resulted in increased antifungal activity of Eurotium chevalieri and Emericella foveolata extracts but decreased the effects of Talaromyces tratensis and T. stipitatus extracts. Meanwhile, the co-culturing of marine-derived fungi with autoclaved B. subtilis resulted in decreased antifungal activity of E. foveolata, T. stipitatus and T. tratensis but slightly increased activity of E. chevalieri. A significant effect of the co-culture of E. chevalieri and B. subtilis resulted in an increased antifungal activity compared to the axenic cultures with complete inhibition of mycelial growth of all the plant pathogens tested, whereas the extract from fungus alone displayed percentage inhibition ranging from 33.11-100% at 10 g L-1 concentration. Overall, the effect of coculturing with live or autoclaved B. subtilis had positive, negative or no effect on the antifungal activities of the tested marine-derive fungi against plant pathogens in vitro.

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Induction of new metabolites from the endophytic fungus Bionectria sp. through bacterial co-culture

Cited by 40 publications

References 30 publications

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Metabolites from Clonostachys Fungi and Their Biological Activities

Effects of Co-culturing with Live and Autoclaved Bacillus subtilis on Antagonistic Activity of Marine Fungi against Plant Pathogens

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