2022
DOI: 10.1159/000527576
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Induction of Oxidative Stress and Alteration of Synaptic Gene Expression in Newborn Hippocampal Granule Cells after Developmental Exposure to Aroclor 1254

Abstract: Introduction: Hippocampal newborn neurons integrate into functional circuits where they play an important role in learning and memory. We previously showed that perinatal exposure to Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs) associated with alterations of cognitive function in children, disrupted the normal maturation of excitatory synapses in the dentate gyrus. We hypothesized that hippocampal immature neurons underlie some of the cognitive effects of PCBs. Methods: We used newly-… Show more

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Cited by 4 publications
(2 citation statements)
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“…22 Our results showing enriched mitochondrial and oxidative phosphorylation gene pathways are also consistent with a transcriptomic analysis of newborn mouse dentate granule cells following perinatal exposure to Aroclor 1254, a commercial PCB mixture. 23 What is unique about our investigation is the integration of placenta and fetal brain and the demonstration of profound sex differences in the transcriptional response to prenatal PCB exposure in both brain and placenta.…”
Section: Discussionmentioning
confidence: 99%
“…22 Our results showing enriched mitochondrial and oxidative phosphorylation gene pathways are also consistent with a transcriptomic analysis of newborn mouse dentate granule cells following perinatal exposure to Aroclor 1254, a commercial PCB mixture. 23 What is unique about our investigation is the integration of placenta and fetal brain and the demonstration of profound sex differences in the transcriptional response to prenatal PCB exposure in both brain and placenta.…”
Section: Discussionmentioning
confidence: 99%
“…But once their presence is attested and quantified, their association with endocrine-disrupting activities needs to be causally tested using laboratory models. An example of the consequences of early exposure to PCB, here Aroclor 1254, on neuroendocrine dysfunction is provided by Pinson and her colleagues [6]. Using a mouse model, they show that early maternal exposure to Aroclor 1254, a commercial mixture of polychlorinated biphenyls (PCBs) associated with alterations of cognitive functions in children [7] and altered levels of thyroid hormones (this issue and [4]), has a significant and cell-type-specific impact on neurogenesis in the hippocampus later in life.…”
mentioning
confidence: 99%