Induction of parturition in the sow and incidence of splayleg syndrome in the newborn piglet

Sellier, Pierre; Dando, Étienne; Dando, Pierre

doi:10.1051/animres:19990301

Cited by 12 publications

(10 citation statements)

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“…Even a decade after the initial description (29), PCS was often considered a consequence of insufficient intrauterine nutrition (6,20). Nevertheless, numerous investigations presented convincing evidence for a genetic background of PCS (26,(52)(53)(54). Because environmental factors exerted a major influence on incidence and severity of the syndrome (55), it was noted that an environmental "threshold" seemed to be necessary for clinical manifestation of PCS (18).…”

Section: Genetic Characterization Of the Splay Leg Syndromementioning

confidence: 99%

“…Because environmental factors exerted a major influence on incidence and severity of the syndrome (55), it was noted that an environmental "threshold" seemed to be necessary for clinical manifestation of PCS (18). Quantitative, genetic analyses revealed an oligo-or polygenic heredity with an estimated heritability of up to 0.47 (22,54).…”

Section: Genetic Characterization Of the Splay Leg Syndromementioning

confidence: 99%

“…Induced farrowing as a common practice in the industrial pig production was also discussed as a possible cause of splay leg syndrome from the 1970's until recently (54). It was shown that induced farrowing increased the relative rate of piglet morbidity (74), but further studies found only a weak correlation between reduction of gestation length by induced farrowing and the incidence of PCS (54,75,76).…”

Section: Current Statusmentioning

confidence: 99%

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Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

2021

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The porcine congenital splay leg syndrome (PCS), even though being of transient nature, is still one of the most important causes for piglet losses due to its high incidence and mortality. Although, described decades ago, the pathogenetic mechanism is still elusive. Numerous, mostly descriptive studies characterized the syndrome at clinical, histological and cellular levels but resulted in a highly diverse picture of the syndrome. Broad variability in phenotypical expression and, in case of proper care, the rapid recovery of affected animals complicated a systematical analysis of the underlying pathogenesis. Although, several environmental factors were discussed as potential causes of PCS, most of the evidence points to a hereditary basis of PCS. Nevertheless, only few of the suggested candidate genes from transcriptome and mapping analyses, like F-box protein 32 (FBXO32), could be confirmed so far. Only recently, a genome wide association study revealed genomic regions on five porcine chromosomes and named a number of potential candidate genes, among them homer scaffold protein 1 (HOMER1). This new candidate—a cellular scaffold protein—plays a role in a plethora of cellular signaling cascades, and is not only involved in skeletal muscle differentiation but also critical for muscular function. In this review, we critically elucidate the current state of knowledge in the field and evaluate current achievements in the identification of the pathogenetic mechanism for the syndrome.

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Section: Genetic Characterization Of the Splay Leg Syndromementioning

confidence: 99%

Section: Genetic Characterization Of the Splay Leg Syndromementioning

confidence: 99%

Section: Current Statusmentioning

confidence: 99%

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Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

2021

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“…Le « splay-legs » ou les tremblements congénitaux sont généralement décrit comme des anomalies survenant par crises ponctuelles dans les élevages. Van Der Heyde et al (1989), Sellier et al (2008) ont rapporté une fréquence supérieure de cas de « splay-legs » chez les porcelets nés aux mois de mai, août et novembre ; la prévalence de cas de tremblements congénitaux serait également supérieure à l'automne.…”

Section: A) La Saisonunclassified

Les anomalies congénitales héréditaires chez le porc

et al. 2020

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Les anomalies congénitales sont définies comme des défauts de structure ou de fonction présents à la naissance. Bien que la fréquence des anomalies congénitales soit relativement faible, leur impact en production porcine est significatif. Elles provoquent le plus souvent un mal-être des animaux et une dépréciation des carcasses à l’abattoir induisant des pertes économiques. Les anomalies congénitales peuvent être de nature diverse, mais les défauts les plus courants rencontrés chez le porcelet sont de type urogénital (les hernies inguinales et scrotales, la cryptorchidie et l’intersexualité). Ces défauts peuvent être dus à des problèmes nutritionnels, aux conditions d’environnement ou à la conduite de l’élevage, mais une part de leur déterminisme est très souvent génétique. Les développements récents des outils de génomique permettent désormais d’entreprendre, à grande échelle, des études d’association afin d’identifier les régions chromosomiques des gènes impliqués. L’identification des mutations causales est devenue une priorité afin de proposer de nouveaux schémas de sélection. L’objectif de cet article est de présenter une synthèse des connaissances génétiques sur les anomalies congénitales les plus fréquentes chez le porc et les stratégies mises en œuvre pour gérer ces défauts en sélection.

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“…Therefore, Kirkwood (1999) recommended that farrowing induction should not be performed more than two days before the average gestation length at farm level. When farrowing induction is performed too early, problems such as higher risk of stillborn piglets, lower birth weight and growth, splay-leg, neonatal mortality, the need for antimicrobial treatment and changes in the composition of colostrum may occur (King and others 1979, Friendship and others 1990, Jackson and others 1995, Sellier and others 1999, Walkiewicz and others 2006, Gunvaldsen and others 2007, Foisnet and others 2011). …”

Section: Introductionmentioning

confidence: 99%

Effectiveness of different farrowing induction protocols in sows using alphaprostol on day 114 of gestation

Decaluwé

Janssens

Englebienne³

et al. 2014

Veterinary Record

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Farrowing induction in sows is frequently applied and different protocols were described. Most studies induce farrowing between day 111 and 113 of gestation, but hardly any later during gestation. The aim of this study was to investigate the effects of different induction protocols when applied on d114 of gestation. We randomly assigned 118 sows to four treatment groups: single injection of prostaglandin (1×PG), prostaglandin combined with oxytocin 24 hours later (PG+OT), half the dosage of prostaglandin twice with six hours interval (2×1/2PG), and a control group of which farrowing wasn't induced. All injections were administered intramuscularly in the neck on day 114 of gestation. A significantly higher percentage of sows started farrowing between 22 and 32 hours after induction in the PG+OT-group (68 per cent) and the 2×1/2PG-group (52 per cent) compared to the control group (23 per cent). The 1×PG-group (46 per cent) tended to differ from the control group (P=0.087). More sows from the PG+OT-group were constipated at farrowing (P=0.042). Farrowing duration, birth interval, per cent stillborn piglets, dystocia and other variables were similar between the groups. In the present herd and with continuous farrowing supervision, applying PG+OT or 2×1/2PG on d114 of gestation was efficient to induce onset of farrowing in most of the sows 22-32 hours after induction without considerable negative effects.

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Induction of parturition in the sow and incidence of splayleg syndrome in the newborn piglet

Abstract: -The relationship between gestation length and incidence of the splayleg condition in newborn piglets (two

Cited by 12 publications

References 3 publications

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

Congenital Splay Leg Syndrome in Piglets—Current Knowledge and a New Approach to Etiology

Les anomalies congénitales héréditaires chez le porc

Effectiveness of different farrowing induction protocols in sows using alphaprostol on day 114 of gestation

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