Induction of parturition in the mare with prostaglandin F2α

Klem, Michelle; Kreider, J.L.; Harms, P. G.; Potter, G.D.; Kraemer, D.C.; Godke, R.A.

doi:10.1016/0090-6980(82)90180-0

Cited by 13 publications

(5 citation statements)

References 11 publications

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“…Again, this would be consistent with a mass discharge effect that typically would involve rapid nervous stimulation of the adrenal medulla [20]. In addition, the sweating, diarrhea, and signs of colic displayed by the geldings receiving the higher three doses of substance P may indicate a release of PGF2α, given that these side effects are often seen when PGF2α is administered to mares for luteolysis [21,22].…”

Section: Discussionmentioning

confidence: 56%

Responses of Adenohypophyseal Hormones to Substance P Administration in Geldings: Comparison to Responses After Brief Exercise and Sulpiride Administration

Thompson

Valencia

Oberhaus

2016

Journal of Equine Veterinary Science

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Nine adult geldings were used in three experiments to study the possible role of substance P in the prolactin responses to non-dopaminergic stimuli. Experiment 1 was performed as an incomplete Latin square design to determine the secretory responses of prolactin, growth hormone (GH), adrenocorticotropic hormone (ACTH), thyroid stimulating hormone (TSH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) to intravenous administration of substance P. Doses tested and compared to no peptide (0 dose, control) were 62, 125, 250, and 500 ug of substance P. The three highest doses of peptide caused an immediate rise in heart rate, sweating, salivation, rhinorrhea, stretching of hind legs, and defecation. The lowest dose (62 ug) caused minor sweating, some rhinorrhea, and a rise in heart rate. Recovery from these physical responses was complete in approximately 30 min. All doses of substance P caused an immediate rise (P < 0.01) in plasma prolactin concentrations, with the three highest doses producing similar responses, and the 62 ug dose producing a minimal response (P < 0.05). Concentrations of ACTH (P < 0.01) and GH (P = 0.05) also increased after substance P administration; concentrations of LH, FSH, and TSH were unaffected. Experiment 2 compared the effects of brief exercise on hormonal characteristics. Two minutes of trotting increased (P < 0.01) plasma concentrations of GH, ACTH, and prolactin, as well as LH (P = 0.055). Experiment 3 determined the relative responses of prolactin to a fixed dose of sulpiride (0.1 mg/kg of body weight). In general, the prolactin responses to substance P were similar to those after exercise, which were both generally less than after sulpiride. These data are consistent with a possible role of substance P in the prolactin response to stressful stimuli.

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Section: Discussionmentioning

confidence: 56%

Responses of Adenohypophyseal Hormones to Substance P Administration in Geldings: Comparison to Responses After Brief Exercise and Sulpiride Administration

Thompson

Valencia

Oberhaus

2016

Journal of Equine Veterinary Science

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“…Prostaglandins have been shown to be necessary at the end of steroid treatment to ensure the regression of remaining corpora lutea [Loy et al, ; Blanchard et al, ]. Unfortunately, prostaglandins and their analogues have also been shown to cause adverse effects in domestic equids, including sweating, hypothermia, increased respiratory rate, and diarrhea [Klem et al, ; Plumb, ]. Previous studies have described the use of a microdose (∼25 ug) of cloprostenol to diminish the systemic response in mares to prostaglandins and their analogues [Nie et al, ].…”

Section: Discussionmentioning

confidence: 99%

Estrous cycle synchronization in the Persian onager (Equus hemionus onager)

Beest¹,

Schook

2016

Zoo Biology

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The endangered Persian onager (Equus hemionus onager) has experienced significant population declines over the past century due to poaching, habitat destruction, and resource competition. Remaining animals in zoos and the wild are regionally isolated. Artificial insemination (AI) may be particularly useful as a means of aiding in global genetic management of these isolated populations. The first successful AI in onagers was performed in 2009 utilizing urinary hormone analyses and regular transrectal ultrasound examinations that required specialized handling devices. A method for estrous synchronization in this species would alleviate the need for daily handling and provide a more feasible approach to AI. This study tested long-acting controlled-release preparations of estradiol and progesterone, followed by a single injection of prostaglandin 10 days later, in six adult female Persian onagers to determine whether ovulation would occur within a narrow window of time. Serial transrectal ultrasound exams were performed to determine the day of ovulation following hormone treatment. Means and standard deviations were determined for the lengths of follicular and luteal phases, follicle sizes, and time to ovulation, and compared to historical data in this species. All six onagers ovulated between Days 18 and 22, with three females ovulating on Day 19, as determined by the presence of a corpus luteum. This is an apparently safe and effective method for the synchronization of estrous cycles in the Persian onager, and may be used to develop a timed AI protocol for use at institutions that do not have specialized handling facilities to enable regular transrectal ultrasound.

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“…Pashen and Allen (1979) reported that labour was weak and ineffective in mares carrying gonadectomised pony fetuses in which plasma oestrogen concentrations were at baseline. Some authors (Alm et al 1975;Hillman 1975;Klem et al 1982) have reported that oestrogens administered in conjunction with other inducing agents may shorten the induction interval and help relax the cervix, although Jeffcott and Rossdale (1977) found that stilboestrol was not essential for relaxing the cervix when administered in conjunction with oxytocin.…”

Section: Oestrogensmentioning

confidence: 99%

“…or i.v. is reported to be generally ineffective unless mares are close to foaling, given multiple doses, or given oestrogen or dexamethasone concurrently (Alm et al 1975;Bristol 1982;Klem et al 1982). Fluprostenol (250 µg i.m.)…”

Section: Prostaglandins (Pgs)mentioning

confidence: 99%

Induction of parturition in the healthy mare

Ousey¹

2003

Equine Veterinary Education

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Induction of parturition in the mare with prostaglandin F2α

Cited by 13 publications

References 11 publications

Responses of Adenohypophyseal Hormones to Substance P Administration in Geldings: Comparison to Responses After Brief Exercise and Sulpiride Administration

Responses of Adenohypophyseal Hormones to Substance P Administration in Geldings: Comparison to Responses After Brief Exercise and Sulpiride Administration

Estrous cycle synchronization in the Persian onager (Equus hemionus onager)

Induction of parturition in the healthy mare

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