Induction of Parturition with Aglepristone in the Majorera Goat

Batista, M.; Reyes, Ramón Arista; Santana, M; Alamo, D; Vilar, Jose M. G.; González, F.; Cabrera, Fernando; Gracia, A.

doi:10.1111/j.1439-0531.2011.01759.x

Cited by 11 publications

(6 citation statements)

References 32 publications

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“…In the current study, PGF 2α injection induced kidding within 29.00±11.37 hours . This compared favorably with the report of Batista et al (2011) in which induction occurred within 30 to 34 hours without any effect on foetal viability or the incidence of retained placenta. Placenta was expelled in the first 6 hours after the induced natural parturition.…”

Section: Discussionsupporting

confidence: 78%

Approaches for elective induction of kidding in the Sudanese Nubian goats

Bakri¹,

Jubara²

2020

J. Anim. Sci. Vet. Med.

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In the Sudan, the husbandry system of goats in urban and peri-urban areas subject them to kid in streets, under vehicles and in dirty environments thus exposing the newly born kids to the risk of predators, crush under vehicles, exposure to diseases and occasionally death due to the unattended difficult birth. Therefore, need to control time of kidding for survivability of kids and future fertility of the dam was the overall objective of this study. In a randomized block design experiment, twenty mid-term pregnant Nubian goats were assigned to four treatment groups namely, control (1), prostaglandin F2α (PGF2α) treatment (2), dexamethasone treatment (3) and cesarean operation (4), with an overall aim of selecting an appropriate tool for elective induction of parturition that preserves life and health and future fertility of does as well as production of viable kids. The hormonal treatments and caesarean operation were performed on day 140 of gestation in all the treatments. The shortest induction time was seen with caesarean section (1.25±0.72 hours) and dexamethasone showed the longest time for induction (57.40±9.21 hours) followed by PGF2α treatment (29.00±1.37 hours). All the treatments resulted to ease of kidding, preserved the reproductive life of does and produced viable kids, except caesarean operation that significantly resulted in delayed placenta expulsion (22.20±2.86 hours) and delayed the time for resumption of ovarian cyclicity (58±5.25 days). In conclusion, the study recommended the use of prostaglandin F2α hormone as a valuable tool for strategic elective induction of kidding in the Sudanese Nubian goats because of its shortest induction time, early placental expulsion and return to ovarian activities.

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Section: Discussionsupporting

confidence: 78%

Approaches for elective induction of kidding in the Sudanese Nubian goats

Bakri¹,

Jubara²

2020

J. Anim. Sci. Vet. Med.

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“…At the 142nd gestation day, IP with dexamethasone synchronized parturition without dystocia (38). Repeated doses (15 mg/kg) of aglepristone or its combinations have been used for IP in dogs (19), and this drug has also been applied as a unique dose (5-3.3-2.5-1.5 mg/kg) in goats at the 145th gestation day for IP (3). Because the incidence of retained fetal membranes and neonatal mortality was high at a 1.5 mg/kg dose in goats (3), we used 2.5 mg/kg of aglepristone in combination with dexamethasone in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Glucocorticoid usage is a well-known conventional choice to terminate gestation in the veterinary field (1,5,26). Because progesterone plays a primary role in continuing gestation, the application of antiprogestine drugs (mifepristone or aglepristone) has been popular in recent studies (3,12,19,21).…”

Section: Introductionmentioning

confidence: 99%

“…The hormonal mechanisms of the inductive drugs and their physiological effects in the newborns have been discussed in the literature (3,10,19,20,29,30,34,40); however, the advantages and disadvantages of the IP methods have not been studied thoroughly. Here, we aimed to compare the prolactin and oxytocin levels of ewes induced with different IP methods as well as the IgG levels of the colostrum and the serum IgG levels of lambs fed colostrum.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Salci¹,

Demirbilek²,

Güneş³

et al. 2018

Tierarztl Prax Ausg G

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SummaryObjective: This study aimed to compare different induction of parturition (IP) methods in terms of endocrinological and immunological parameters in ewes and lambs. Materials and methods: A total of 24 ewes and their respective 24 lambs were studied. Groups of six ewes were induced on the 138th day: groups I (control), II (dexamethasone), III (aglepristone) and IV (aglepristone + dexamethasone). Blood samples were taken from the ewes from IP to 2 days postpartum at 12-hour intervals for the prolactin and oxytocin analyses. Colostrum and blood samples were collected from the lambs at 0, 12, 24, 36 and 48 hours for the IgG analysis. The prolactin, oxytocin and IgG levels were measured by ELISA. Results: A significant difference was found in prolactin levels in all groups and in the colostral IgG level in group IV with respect to the sampling time. Additionally, a significant difference in prolactin level was found at 24 hours postpartum between group IV and groups I and III. A significant difference in the colostral IgG level was determined at 24 hours after parturition between group III and the other groups and at 48 hours after parturition between groups II and III. A positive and significant correlation between the colostral and serum IgG levels of the lambs was found at 24 hours in groups I and II. Conclusion and clinical relevance: Although varying individual results were found within the groups, the endocrinological and immunological results did not suggest any superiority among the IP methods. Considering the presented study results, a single dose of aglepristone may be used alone or in combination with dexamethasone for IP.

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“…In one of these reviews, it was shown that congenital hyperplasia of the fetus resulting from disturbances in cortisol production causes post-term births. In some studies, an association has been observed between stress in the mother and premature childbirth [5] .…”

Section: Introductionmentioning

confidence: 99%

Effect of intramuscular administration of dexamethasone on the duration of labor induction

Elmaraghy

Refaie

Labib

et al. 2018

Evidence Based Women's Health Journal

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Introduction: induction of labor is a common obstetric procedure which is performed for a variety of medical and nonmedical indications. If the cervix is unfavorable, prior ripening of the cervix makes induction of labor easier and more successful. There are different methods for ripening of the cervix and making it ready for induction. These methods included medical methods such as the administration of prostaglandins and mechanical methods such as extra amniotic saline infusion, traction on the cervix with Foley catheter and laminaria. Aim: The aim of the study is to evaluate the efficacy of intramuscular dexamethazone injection prior to induction in improving progression and duration of labour phases. Subjects and Methods: This study started with 100 Nulliparous Pregnant women who were conducted at the labor wards of Ain-Shams Maternity Hospital. The studied subjects were randomized into two groups ; dexamethasone group (group A) including 50 Nulliparous women (N=50) and control group (group B) including 50 Nulliparous woman (N=50). Results: In this study, the duration of active and second stages decreased without changing the mode of delivery. The study showed no significant statistical differences between the two studied groups regarding fetal heart rate. The duration of second stage in dexamethasone group was shorter than in the control group. Dexamethasone intramuscularly prior to induction significantly shortens duration of normal labor in normal parturient with minimal complications. Conclusion: An intramuscular injection of dexamethasone before labor induction shortens the duration of labor induction by decreasing the interval between the initiation of induction and the beginning of the active phase, duration of active phase and duration of second stage of labor with no observed maternal or neonatal complications. Recommendation: Further research with more patients undertaken for the assessment of the effects of the corticosteroids on the duration of labor on the patients with unfavorable cervix as well as maternal and perinatal morbidity and mortality rate.

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Induction of Parturition with Aglepristone in the Majorera Goat

Cited by 11 publications

References 32 publications

Approaches for elective induction of kidding in the Sudanese Nubian goats

Approaches for elective induction of kidding in the Sudanese Nubian goats

Comparison of the endocrinological and immunological results of different induction of parturition methods in ewes

Effect of intramuscular administration of dexamethasone on the duration of labor induction

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