2003
DOI: 10.1016/s1383-5718(02)00245-0
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Induction of poly(ADP-ribosyl)ation and DNA damage in human peripheral lymphocytes after treatment with (−)-epigallocatechin-gallate

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Cited by 40 publications
(34 citation statements)
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“…Some researchers showed that tannic acid antioxidant/pro-oxidant behaviour is a dose-dependent manner because an increase in non-toxic concentrations of tannic acid caused a slight non-significant increase of O 2 -, NO and malondialdehyde (MDA). It seems that low concentrations of tannic acid are beneficial for cells, as scavengers for ROS intermediates, causing prevention of forming ROS and the concomitant enhancement of lipid peroxidation (Salminen et al, 2001;Bertram et al, 2003;Perron and Brumaghim, 2009). …”
Section: Effects Of Tannic Acid On Broilersmentioning
confidence: 99%
“…Some researchers showed that tannic acid antioxidant/pro-oxidant behaviour is a dose-dependent manner because an increase in non-toxic concentrations of tannic acid caused a slight non-significant increase of O 2 -, NO and malondialdehyde (MDA). It seems that low concentrations of tannic acid are beneficial for cells, as scavengers for ROS intermediates, causing prevention of forming ROS and the concomitant enhancement of lipid peroxidation (Salminen et al, 2001;Bertram et al, 2003;Perron and Brumaghim, 2009). …”
Section: Effects Of Tannic Acid On Broilersmentioning
confidence: 99%
“…Catechin inhibits the activities of various proteins attached to DNA, such as DNA polymerase, cAMP-response element-binding protein, DNA methyltransferase, and DNA topoisomerase (21)(22)(23)(24)(25)(26). These reactions are likely affected by EGCG binding to DNA and RNA.…”
Section: Discussionmentioning
confidence: 99%
“…Catechins induce apoptosis in cells and sometimes cause DNA damage (21)(22)(23)(24)(25)(26), phenomena that are due to oxidative stress. However, this might be triggered by the direct binding of catechins to DNA.…”
Section: Discussionmentioning
confidence: 99%
“…EGCG는 녹차 catechins의 대부분을 차지하며 전체 녹차 내 총 폴리페놀의 약 40%에 해당된다 (3). EGCG는 녹차 catechins 중 가장 잘 알려진 활성 물질이지만 EGCG는 생체이용률이 낮고 중성 이나 알칼리성 용액에 불안정성하다는 제한점이 있으며(4) 특히 EGCG은 DNA 손상을 야기하며 인체 세포주에서는 염색체이상(chromosome aberration)과 자매염색분체교환 (sister chromatid exchanges)을 유도하고 (5,6), 동물실험에 서 대장암 유발을 강화함이 보고되기도 하였다 (7,8 하게 활용되고 있다 (20 …”
Section: 명하는 주된 성분이다 녹차의 Catechins에는 (-)-Epicatechin(ec) (-)-Epicatunclassified