Induction of postural asymmetry in an intact recipient by brain extract from a donor with the same syndrome

Vartanyan, G. A.; Balabanov, Yu. V.

doi:10.1007/bf00799571

Cited by 3 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Suboccipitally injected peptide fractions of cerebrospinal fluid (CSF) or brain extract from an animal with model asymmetric central motor disorders caused by unilateral removal of the motor cortex induces in intact recipient the symptoms similar to those observed in the donor [1]. Peptides from the brain of animal with recovered motor function eliminate pathological asymmetry in recipients with such motor disorders in the acute phase [2].…”

Section: Abstract: Motor Cortex; Partial Decortication; Recovery Of mentioning

confidence: 99%

Effect of donor cerebrospinal fluid on the recovery of motor function in rats after partial decortication

Ptitsyna

Novikova

1997

Bull Exp Biol Med

View full text Add to dashboard Cite

The ability of donor cerebrospinal fluid from different sources the recover motor functions in partially decorticated rats is estimated. Cerebrospinal fluid from frogs, which have no cortex, and cerebrospinal fluid from donor rats obtained immediately or long after decortication hampers normal recovery of motor function in the recipient rats, while cerebrospinal fluid from intact adult or neonatal rats slightly decreases behavioral manifestations of the motor cortex damage in the recipients. Key Words: motor cortex; partial decortication; recovery of motor function; cerebrospinal fluidSuboccipitally injected peptide fractions of cerebrospinal fluid (CSF) or brain extract from an animal with model asymmetric central motor disorders caused by unilateral removal of the motor cortex induces in intact recipient the symptoms similar to those observed in the donor [1]. Peptides from the brain of animal with recovered motor function eliminate pathological asymmetry in recipients with such motor disorders in the acute phase [2]. It was shown that injection of brain extracts from animals with compensated cortical damage into animals 2-6 days after a similar cortical damage accelerates motor function recovery in the recipient [2,4]. However, CSF from compensated animals administered 24 h after cortical damage slowed the recovery of motor function in the recipients, whereas CSF from animals with acute cortical damage optimized the recovery process [3].In the present study we examined the effects of CSF from different donors obtained immediately or long after decortication and CSF from neonatal rats on motor function recovery in partially decorticated recipient rats. MATERIALS AND METHODSThe recipients were random-bred male albino rats weighing 180-200 g. In all recipients, the zone re-I. PI Pavlov Department of Physiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg presenting the right hind limb and partly the right forelimb in the motor cortex of the left hemisphere was removed by aspiration under hexenal anesthesia. This removed zone had the following boundaries (mean values): A = 2 mm, P = 4 mm, and L = 0.5-4 mm from the bregma. Six experimental series were performed, using 8-10 rats per series. In series I-V, rats received 50 gl CSF taken from donor animals and contained in the sponge by which the aspirated cerebral tissue was replaced. In rats of series VI (controls), the sponge replacing the aspirated tissue contained no CSF. Donors were intact 2-day-old rats in series I, intact adult rats in series II, adult flogs in series III, and adult rats 3 days and 4.5 months after decortication (similar to that performed in the recipients) in series IV and V, respectively. Cerebrospinal fluid was obtained by puncturing the great occipital cistern. All operated recipients were tested for supportive function by measuring the distance between the first and the fifth fingers of the hind limbs in rat maintained in the upright posture (a modification of Hasegawa's method [7]); 10 measureme...

show abstract

Section: Abstract: Motor Cortex; Partial Decortication; Recovery Of mentioning

confidence: 99%

Effect of donor cerebrospinal fluid on the recovery of motor function in rats after partial decortication

Ptitsyna

Novikova

1997

Bull Exp Biol Med

View full text Add to dashboard Cite

show abstract

Spinal Fixation: Long-Term Alterations in Spinal Reflex Excitability with Altered or Sustained Sensory Inputs

Patterson

2001

Spinal Cord Plasticity

View full text Add to dashboard Cite

Structural specificity of factors involved in chemical regulation of muscle tone at the spinal level

Vartanyan¹,

Shatik²,

Tokarev³

et al. 1989

Bull Exp Biol Med

View full text Add to dashboard Cite

Induction of postural asymmetry in an intact recipient by brain extract from a donor with the same syndrome

Cited by 3 publications

References 2 publications

Effect of donor cerebrospinal fluid on the recovery of motor function in rats after partial decortication

Effect of donor cerebrospinal fluid on the recovery of motor function in rats after partial decortication

Spinal Fixation: Long-Term Alterations in Spinal Reflex Excitability with Altered or Sustained Sensory Inputs

Structural specificity of factors involved in chemical regulation of muscle tone at the spinal level

Contact Info

Product

Resources

About