Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA)

Firouzmand, Hengameh; Badiee, Ali; Khamesipour, Ali; Shargh, Vahid Heravi; Alavizadeh, Seyedeh Hoda; Abbasi, Azam; Jaafari, Mahmoud Reza

doi:10.1016/j.actatropica.2013.07.021

Cited by 45 publications

(29 citation statements)

References 54 publications

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“…These results suggested that immune modulation using NPs might be a practical approach to improve the safety of LZ. Interestingly, mice immunized with DOTAP liposomes without any additive and containing SLA showed significantly smaller footpad swelling and the lowest spleen and footpad parasite burden after the challenge, accompanied by the high IFN-γ, lower IL-4 level, and higher IgG2a antibody titer than that of control groups (Firouzmand et al, 2013).…”

Section: Nanomedical Prophylactic Strategiesmentioning

confidence: 96%

Nanomedical Therapeutic and Prophylaxis Strategies Against Intracellular Protozoa in the Americas

Morilla

Romero

2015

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

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Section: Nanomedical Prophylactic Strategiesmentioning

confidence: 96%

Nanomedical Therapeutic and Prophylaxis Strategies Against Intracellular Protozoa in the Americas

Morilla

Romero

2015

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

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“…The intrinsic adjuvanticity of the DOTAP-nanoliposomes as an antigen delivery system induces appropriate Th1 type of immune response and protection against L. major infection as compared to free SLA or free liposome [34].…”

Section: Nanoliposomes As Vaccinesmentioning

confidence: 99%

“…To induce a Th1 type of immune response and protection against Leishmania major infection, DOTAP liposomes act as a suitable adjuvant and delivery system as compared to free liposome or free SLA [34].…”

Section: Other Diseasesmentioning

confidence: 99%

Multidynamic Liposomes in Nanomedicine: Technology, Biology, Applications, and Disease Targeting

Ghosh

Ansar²

2014

Nanoparticles' Promises and Risks

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Biocompatible and biodegradable liposome nanomedicine are finding large-scale application in delivery of drugs, RNA, antisense oligonucleotides, DNA, plasmids carrying gene, antioxidants to targeted sites for diagnosis, and treatment at cellular and molecular level of disease both in human and livestock.Conventional drug delivery system suffers from the disadvantage of narrow therapeutic index, poor serum solubility, and nonspecific target effects. Circumventing this problem, liposome drug nanoparticles are designed with the advantage of enhanced permeability, retention effect, selective targeted delivery, stimuli-induced release that can evade the host defense system, cross the bloodbrain barrier, thus conferring, synergetic effects, small interfering RNA (siRNA) co-delivery, multimodality therapies, and oral delivery of therapeutics at disease sites. Liposomes with diverse range of modifications are being designed to generate improvised medicine delivery systems. Immuno-liposomes, linked with antibodies are promising tools for targeted drug delivery to specific cancer cells. In the recent times several anti-cancer agents in nanodelivery systems are under preclinical and clinical studies. Lipid-based liposomal delivery systems of self-amplifying RNA vaccines are showing promising effects.Globally research is being carried out in generating liposomes with higher compatibility within the biological system in targeting a wide array of diseases including cancer, overcoming multidrug resistance, inflammatory diseases, thrombosis, psoriasis, muscular dystrophy, spinal cord injury, neurologic diseases, diabetes, parasite induced diseases, and cardiovascular diseases.

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“…CLNCs combined with antigen (lipid-antigen-nucleic acid-complexes: LANACs) induce both adaptive and innate immunity. LANACs, when used as vaccines, have conferred protection against a variety of infectious agents (Firouzmand et al, 2013; Jones et al, 2010; Phillips et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses

et al. 2016

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Eastern, Venezuelan and western equine encephalitis viruses (EEEV, VEEV, and WEEV) are mosquito-borne viruses that cause substantial disease in humans and other vertebrates. Vaccines are limited and current treatment options have not proven successful. In this report, we vaccinated outbred mice with lipid-antigen-nucleic acid-complexes (LANACs) containing VEEV E1 + WEEV E1 antigen and characterized protective efficacy against lethal EEEV, VEEV, and WEEV challenge. Vaccination resulted in complete protection against EEEV, VEEV, and WEEV in CD-1 mice. Measurements of bioluminescence and plaque reduction neutralization tests (PRNTs) indicate that LANAC VEEV E1 + WEEV E1 vaccination is sterilizing against VEEV and WEEV challenge; whereas immunity to EEEV is not sterilizing. Passive transfer of rabbit VEEV E1 + WEEV E1 immune serum to naive mice extended the mean time to death (MTD) of EEEV challenged mice and provided significant protection from lethal VEEV and WEEV challenge.

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Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA)

Cited by 45 publications

References 54 publications

Nanomedical Therapeutic and Prophylaxis Strategies Against Intracellular Protozoa in the Americas

Nanomedical Therapeutic and Prophylaxis Strategies Against Intracellular Protozoa in the Americas

Multidynamic Liposomes in Nanomedicine: Technology, Biology, Applications, and Disease Targeting

Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses

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