Induction of protein aggregation in zebrafish embryos as a method for the screening of new drugs or mutations against proteinopathies

Abstract

Graphical abstract

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

“…These models offer the advantage of in vivo imaging at the subcellular resolution and with relatively low cost compared with larger animal models. Moreover, these models allow for exploring protein aggregation mechanisms in living organisms (David et al, 2010;Lobos-Ruiz et al, 2018;Tsuboyama et al, 2020) and are powerful for high-throughput screening of therapeutic compounds for neurodegenerative diseases (Chen et al, 2015;Franç ois-Moutal et al, 2019;Lobos-Ruiz et al, 2018).…”