Induction of reverse development in two marine Hydrozoans

Schmich, Jürgen; Kraus, Yulia; Vito, Doris De; Graziussi, Daria; Boero, Ferdinando; Piraino, Stefano

doi:10.1387/ijdb.062152js

Cited by 55 publications

(40 citation statements)

References 58 publications

(88 reference statements)

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“…The shrinkage of a polyp colony and its subsequent expansion is referred to as "renovation." Strikingly, in some hyrozoans, a variety of chemical and environmental stresses can promote "reverse development" in immature medusae, when cells change their properties such that the features of a medusa are replaced by the differentiation of polyp-like structures that initiate the formation of a new polyp colony (Müller 1913;Piraino et al 2004;Schmich et al 2007). At least, in principle, this cycle of growth and reverse development can occur indefinitely.…”

Section: Rejuvenation In Hydrozoansmentioning

confidence: 99%

Indeterminate Growth: Could It Represent the Ancestral Condition?

Hariharan

Wake

2015

Cold Spring Harb Perspect Biol

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Section: Rejuvenation In Hydrozoansmentioning

confidence: 99%

Indeterminate Growth: Could It Represent the Ancestral Condition?

Hariharan

Wake

2015

Cold Spring Harb Perspect Biol

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“…(d) Changing of current dogma(s) such as disposable soma [41], irreversibility of aging [42], and germ/somatic cell barriers [43], as demonstrated by the capacity of whole body regeneration from small fragments [26] or the ability to rejuvenate [44], are easily found in marine/aquatic invertebrates.…”

Section: Potential For Innovation Versus Risk Levelmentioning

confidence: 99%

Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications

et al. 2018

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The “stem cells” discipline represents one of the most dynamic areas in biomedicine. While adult marine/aquatic invertebrate stem cell (MISC) biology is of prime research and medical interest, studies on stem cells from organisms outside the classical vertebrate (e.g., human, mouse, and zebrafish) and invertebrate (e.g., Drosophila, Caenorhabditis) models have not been pursued vigorously. Marine/aquatic invertebrates constitute the largest biodiversity and the widest phylogenetic radiation on Earth, from morphologically simple organisms (e.g., sponges, cnidarians), to the more complex mollusks, crustaceans, echinoderms, and protochordates. These organisms contain a kaleidoscope of MISC-types that allow the production of a large number of novel bioactive-molecules, many of which are of significant potential interest for human health. MISCs further participate in aging and regeneration phenomena, including whole-body regeneration. For years, the European MISC-community has been highly fragmented and has established scarce ties with biomedical industries in an attempt to harness MISCs for human welfare. Thus, it is important to (i) consolidate the European community of researchers working on MISCs; (ii) promote and coordinate European research on MISC biology; (iii) stimulate young researchers to embark on research in MISC-biology; (iv) develop, validate, and share novel MISC tools and methodologies; (v) establish the MISC discipline as a forefront interest of biomedical disciplines, including nanobiomedicine; and (vi) establish collaborations with industries to exploit MISCs as sources of bioactive molecules. In order to fill the recognized gaps, the EC-COST Action 16203 “MARISTEM” has recently been launched. At its initial stage, the consortium unites 26 scientists from EC countries, Cooperating countries, and Near Neighbor Countries.

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“…The Medusozoa (Turritopsis dohrnii, Hydra, Hydractinia carnea) provide the proof that extant genomes retained the faculties to repeatedly regress into their ancestral life forms and to regenerate [106,107]. Stress may elicit the process (the stress being a needle prick to the medusa in the laboratory).…”

Section: Reversal Of Ontogenesis To the Stage Of Primordial Stem Cellmentioning

confidence: 99%

“…Eventually, the polyp will again bud mature medusae. Here, the immature cells redifferentiated and returned into the service of the cell community (spectacularly illustrated by Günter Plickert et al, Jürgen Schmich et al) [106,107].…”

Section: Reversal Of Ontogenesis To the Stage Of Primordial Stem Cellmentioning

confidence: 99%

The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes

Sinkovics¹

2015

European Journal of Microbiology and Immunology

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Malignantly transformed (cancer) cells of multicellular hosts, including human cells, operate activated biochemical pathways that recognizably derived from unicellular ancestors. The descendant heat shock proteins of thermophile archaea now chaperon oncoproteins. The ABC cassettes of toxin-producer zooxantella Symbiodinia algae pump out the cytoplasmic toxin molecules; malignantly transformed cells utilize the derivatives of these cassettes to get rid of chemotherapeuticals. High mobility group helixloop-helix proteins, protein arginine methyltransferases, proliferating cell nuclear antigens, and Ki-67 nuclear proteins, that protect and repair DNA in unicellular life forms, support oncogenes in transformed cells. The cell survival pathways of Wnt-β-catenin, Hedgehog, PI3K, MAPK-ERK, STAT, Ets, JAK, Pak, Myb, achaete scute, circadian rhythms, Bruton kinase and others, which are physiological in uni-and early multicellular eukaryotic life forms, are constitutively encoded in complex oncogenic pathways in selected single cells of advanced multicellular eukaryotic hosts. Oncogenes and oncoproteins in advanced multicellular hosts recreate selected independently living and immortalized unicellular life forms, which are similar to extinct and extant protists. These uni cellular life forms are recognized at the clinics as autologous "cancer cells".

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Induction of reverse development in two marine Hydrozoans

Cited by 55 publications

References 58 publications

Indeterminate Growth: Could It Represent the Ancestral Condition?

Indeterminate Growth: Could It Represent the Ancestral Condition?

Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications

The cell survival pathways of the primordial RNA-DNA complex remain conserved in the extant genomes and may function as proto-oncogenes

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