2024
DOI: 10.1126/sciadv.adk9001
|View full text |Cite
|
Sign up to set email alerts
|

Induction of somatic cell haploidy by premature cell division

Aleksei Mikhalchenko,
Nuria Marti Gutierrez,
Daniel Frana
et al.

Abstract: Canonical mitotic and meiotic cell divisions commence with replicated chromosomes consisting of two sister chromatids. Here, we developed and explored a model of premature cell division, where nonreplicated, G 0 /G 1 -stage somatic cell nuclei are transplanted to the metaphase cytoplasm of mouse oocytes. Subsequent cell division generates daughter cells with reduced ploidy. Unexpectedly, genome sequencing analysis revealed proper segregation of homologous chromos… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
references
References 52 publications
0
0
0
Order By: Relevance