Induction of suppressor cells by intravenous administration of Bacillus calmette-guérin and its modulation by cyclophosphamide

Bennett, James A.; Mitchell, Malcolm S.

doi:10.1016/0006-2952(79)90649-x

Cited by 12 publications

(1 citation statement)

References 15 publications

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“…These cells were not only associated with tumour growth, but were also a major component of inflammatory and haematopoietic processes 3 , including a presence in neonatal/newborn spleens, adult bone marrow (BM) 3 , and adult spleens following total body irradiation (TBI) 4 . Subsequent studies revealed an increase in NS cells in lymphoid and some parenchymal organs during tumour growth 24, 25 and following Bacillus Chalmette-Guerin (BCG) 26, 27 injection. The tumour-induced granulocytosis, associated lymphopenia 24 , and loss of T-cell function 25 suggested a potential impact on cancer outcome, as well as, therapeutic potential if NS cells were down-regulated.…”

Section: History Of Suppressive Myeloid Cells; Phenotypes and Subsetsmentioning

confidence: 99%

History of myeloid-derived suppressor cells

2013

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Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T-cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies revealed that this hyperplasia was associated with populations of multi-potent progenitor cells identified as myeloid-derived suppressor cells (MDSCs). The discovery and study of MDSCs have provided a wealth of information regarding tumour pathobiology, extended our understanding of neoplastic progression, and modified our approaches to immune adjuvant therapy. In this perspective, we discuss the history of MDSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs, and the host macroenvironment.

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