Induction of the aerobic methylation of arsenic byCandida humicola

Cullen, William R.; McBride, B C; Reimer, Monica

doi:10.1007/bf01685404

Cited by 14 publications

(4 citation statements)

References 5 publications

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“…dimethylarsinate increases the synthesis of trimethylarsine from arsenate two-to three-fold (Cullen, McBride, and Reimer 1979).…”

Section: Discussionmentioning

confidence: 99%

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The reduction of trimethylarsine oxide by Candida humicola

Pickett¹,

McBride²,

Cullen³

et al. 1981

Can. J. Microbiol.

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Trimethylarsine oxide, a probable intermediate in the biological transformation of arsenate, was reduced to volatile trimethylarsine by Candida humicola. A simple assay for the rate of trimethylarsine production from trimethylarsine oxide by the fungus was developed. The optimum pH for the reduction was determined as 5.1-5.2, and the optimum temperature was 40 degrees C. The rate of reduction was directly proportional to cell concentration and followed Michaelis-Menten type kinetics. There was almost no trimethylarsine produced by heated or broken cells. The reaction was inhibited by a number of electron transport inhibitors and uncouplers of oxidative phosphorylation including cyanide, azide, and 2,4-dinitrophenol. The rate of reduction was modified by arsenate, methylarsonate, dimethylarsinate, selenate, and tellurate. Preincubation of cells with trimethylarsine oxide increased the rate of reduction 69-fold; this increase in activity was blocked if the cells were incubated with the protein synthesis inhibitor cycloheximide.

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“…dimethylarsinate increases the synthesis of trimethylarsine from arsenate two-to three-fold (Cullen, McBride, and Reimer 1979).…”

Section: Discussionmentioning

confidence: 99%

“…brevicaulis (Challenger 1945) and Candida humicola (Cox and Alexander 1973;Cullen et al 1977;Cullen, McBride, and Reimer 1979;Cullen, McBride, and Pickett 1979). Methanobacterium produce dimethylarsine by an abbreviated but similar pathway (McBride and Wolfe 197 1).…”

Section: Introductionmentioning

confidence: 99%

The reduction of trimethylarsine oxide by Candida humicola

Pickett¹,

McBride²,

Cullen³

et al. 1981

Can. J. Microbiol.

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“…There is evidence suggesting that inorganic arsenic is extensively methylated. Arsenic methylation occurs in an oxidative methylation reaction in which trivalent forms of arsenic are sequentially methylated to form mono-, di-, and trimethylated products using S-adenosyl methionine (SAM) as the methyl donor and glutathione (GSH) as an essential co-factor [ 47 , 48 ]. Metabolites are primarily excreted in the urine.…”

Section: Reviewmentioning

confidence: 99%

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review

Ortiz-Garcia,

Cipriano Ramírez,

Juarez

et al. 2023

Cureus

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Arsenic exposure is a significant public health issue, with harmful effects caused by its use in commercial products such as car batteries, pesticides, and herbicides. Arsenic has three main compounds: inorganic, organic, and arsine gas. Inorganic arsenic compounds in water are highly toxic. The daily intake of arsenic from food and beverages is between 20 and 300 mcg/day. Arsenic is known for its carcinogenic properties and is classified as a human carcinogen by different institutions. Exposure can lead to oxidative stress, DNA damage, and epigenetic deregulation, which can cause endocrine disorders, altered signal transduction pathways, and cell proliferation. In addition, arsenic can easily cross the placenta, making it a critical concern for maternal and fetal health. Exposure can lead to complications such as gestational diabetes, anemia, low birth weight, miscarriage, and congenital anomalies. Female babies are particularly vulnerable to the negative impact of arsenic exposure, with a higher risk of low weight for gestational age and congenital cardiac anomalies. Therefore, it is crucial to monitor and regulate the levels of arsenic in drinking water and food sources to prevent these adverse health outcomes. Further research is necessary to fully understand the impact of arsenic exposure on human health, especially during pregnancy and infancy, by implementing preventative measures and monitoring the levels of arsenic in the environment.

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“…0 άνθρωπος για να ανταποκριθεί στις σύγχρονες απαιτήσεις της γεωργίας και της Τεχνολογίας, έχε ι προκαλέσει, κατά ένα ποσοστό, την συσσώρευση οργανομεταλλικών ρυπαντών στο περιβάλλον. Είναι εύκολο στο σημείο αυτό,να καταλάβει κανείς και την ανάγκη για κατανόηση της σημασίας της κατεργασίας των αποβλήτων,πριν φθά-- 9 σσυν στους αποδέκτες τους,γta την όσο το δυνατό,τέλεια απομάκρυν ση των οργανομεταλλικών ρυπαντών απ'αυτά. Γενικότερα,είναι προφα νής η ανάγκη για μελέτη των τρόπων,με τους οποίους (α) ο άνθρωπος εισάγει οργανομεταλλικές ενώσεις και οργανσμεταλλοειδή στο περιβάλλον,ή (β) το περιβάλλον,μέσα από τις βιολογικές τροφικές αλυσί δες,μεταφέρει τις βιοδραστικές αυτές ουσίες στον ανθρώπινο οργανι σμό.…”

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Μελετη Πανω Στην Περιβαλλοντικη Μεθυλιωση Των Μεταλλων Υδραργυρου, Κασιτερου Και Μολυβδου Σε Υδατικα Οικοσυστηματα

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Induction of the aerobic methylation of arsenic byCandida humicola

Cited by 14 publications

References 5 publications

The reduction of trimethylarsine oxide by Candida humicola

The reduction of trimethylarsine oxide by Candida humicola

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review

Μελετη Πανω Στην Περιβαλλοντικη Μεθυλιωση Των Μεταλλων Υδραργυρου, Κασιτερου Και Μολυβδου Σε Υδατικα Οικοσυστηματα

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