Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model

Tolerance in Renal Transplantation

“…The central role of the thymus in mediating cellular immunity and graft rejection was established by JFAP Miller, who showed that nude mice tolerated skin allografts because of a marked deficiency of lymphocytes [4]. Conversely, there have been recent studies that show that spleen transplantation in pigs or dogs has a tolerogenic effect on renal transplantation [5,6]. On the basis of the promising results obtained in these animal models, several tolerogenic protocols have been attempted in humans, but most have failed to achieve robust and stable tolerance after renal transplantation.…”