Induction of Tonic Spasms by Carbamazepine: Observations on 2 Infants

Mutoh, Kozo; Okuno, Takehiko; Mitsuyoshi, Izuru; Hayakawa, Takahiro; Hamada, Yasushi; Mikawa, Harukí

doi:10.1111/j.1440-1819.1993.tb02083.x

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…Epileptic Spasms Without Hypsarrhythmia (ESWH), as for ES in general, are commonly treated with hormonal therapy (Eisermann et al, 2006;Ishikawa et al, 2014). OXC and CBZ may induce ES (Mutoh et al, 1993;Veerapandiyan et al, 2012). After failure L.R.D.…”

Section: Discussionmentioning

confidence: 99%

“…Epileptic Spasms Without Hypsarrhythmia (ESWH), as for ES in general, are commonly treated with hormonal therapy (Eisermann et al , ; Ishikawa et al , ). OXC and CBZ may induce ES (Mutoh et al , ; Veerapandiyan et al , ). After failure with several AEDs, we administered VGB, also previously reported as a treatment for ESWH, and seizure freedom and cognitive gains were observed.…”

Section: Discussionmentioning

confidence: 99%

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Epileptic spasms without hypsarrhythmia in infancy and childhood: tonic spasms as a seizure type

Marchi

Seraphim

Corso

et al. 2015

Epileptic Disorders

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Epileptic spasms were defined by the International League Against Epilepsy Task Force on Classification and Terminology in 2001 as a specific seizure type. Epileptic spasms without hypsarrhythmia have been described in some series of patients, occurring either in infancy or childhood. More prolonged epileptic spasms without hypsarrhythmia were previously defined as a different seizure type, and referred to as "tonic spasm seizures". Here, we present a 5-year-old boy who started having epileptic spasms without hypsarrhythmia at 8 months of age, effectively treated with oxcarbazepine. With the withdrawal of medication, epileptic spasms returned. Video-EEG monitoring revealed high-voltage slow waves superimposed by low-voltage fast activity, followed by an electrodecremental phase and a burst of asymmetric fast activity, time-locked to clinical tonic spasm seizures. Brain MRI showed left temporal atrophy with temporal pole grey/white matter junction blurring and ictal PET-CT showed left basal frontal hypermetabolism. Seizures were refractory to several AEDs and vigabatrin was introduced with seizure cessation. Despite efforts to classify epileptic spasms, these are still considered as part of the group of unknown seizure types. In some cases, a focal origin has been suggested, leading to the term "periodic spasms" and "focal spasms". In this case, epileptic spasms without hypsarrhythmia, associated with tonic spasms, may be a variant of focal spasms and might be considered as an epileptic syndrome. [Published with video sequence]A cluster of three tonic spasms, characterized by sudden flexion of the head and proximal muscles, lasting 5, 4.3 and 1 second, respectively. The spasms were accompanied simultaneously by upward deviation of the eyes and oral automatisms at the end.Key words for the video research on www.epilepticdisorders.com

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Epileptic spasms without hypsarrhythmia in infancy and childhood: tonic spasms as a seizure type

Marchi

Seraphim

Corso

et al. 2015

Epileptic Disorders

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“…CBZ may exacerbate typical and atypical absences (31 ,S8-64) as well as atonic (58,95,63), tonic (61,65,66), and myoclonic seizures (58,59,66,67) in patients with generalized epilepsy; the majority of cases were reported in children. Patients who have these seizure types in their history may be particularly at risk, but de novo appearance of these seizures has been reported also in patients who had only tonic-clonic seizures (3 1,58), benign idiopathic partial epilepsy (3 l), juvenile myoclonic epilepsy (JME) (68), unspecified seizure types (68), or frequent multifocal EEG paroxysms without seizures (67).…”

Section: Carbamazepinementioning

confidence: 99%

Antiepileptic Drugs as a Cause of Worsening Seizures

Perucca

Gram

Avanzini³

et al. 1998

Epilepsia

500

329

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Summary:Purpose: Although the paradoxical ability of antiepileptic drugs (AEDs) to increase seizure activity has been recognized for decades, the underlying mechanisms are poorly understood and few systematic studies have addressed this problem. This article is intended to provide a critical review of available literature on this topic.Methods: Information was collected by means of computerized literature searches, screening of journals and textbooks, and consultation with colleagues. Mechanisms which potentially might precipitate underlying drug-induced exacerbation of seizures were considered based on available pharmacologic and clinical knowledge.

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“…The related antiepileptic drug CBZ was also reported to induce spasms in two cases from Japan (Mutoh et al , 1993). The first case was a two‐year‐old girl with partial seizures and secondary generalisation who developed tonic spasms and burst‐suppression pattern on EEG at the age of four months when she was treated with CBZ.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, our case raises the possibility that OXC may induce infantile spasms, and clinicians treating infants who develop spasms while on OXC should be aware of this possibility. The related antiepileptic drug CBZ was also reported to induce spasms in two cases from Japan (Mutoh et al, 1993). The first case was a two-year-old girl with partial seizures and secondary generalisation who developed tonic spasms and burst-suppression pattern on EEG at the age of four months when she was treated with CBZ.…”

Section: Discussionmentioning

confidence: 99%

Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures

Veerapandiyan¹,

Singh²,

Mikati³

2012

Epileptic Disorders

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Oxcarbazepine has been reported to precipitate myoclonic, generalised tonic‐clonic, absence, and complex partial seizures, and carbamazepine to precipitate absences, myoclonic seizures and spasms. Here, we report a one‐year, six‐month‐old girl with complex partial seizures who developed infantile spasms, developmental regression, and hypsarrhythmia during the two weeks directly following initiation of oxcarbazepine (14 mg/kg/day). All of these resolved within a few days after discontinuation of this medication. Although we cannot rule out that the above association may have been coincidental, or that the improvement may have been due to concurrent therapy, this case raises the possibility that oxcarbazepine, like carbamazepine, may precipitate infantile spasms and West syndrome.

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Induction of Tonic Spasms by Carbamazepine: Observations on 2 Infants

Cited by 4 publications

References 2 publications

Epileptic spasms without hypsarrhythmia in infancy and childhood: tonic spasms as a seizure type

Epileptic spasms without hypsarrhythmia in infancy and childhood: tonic spasms as a seizure type

Antiepileptic Drugs as a Cause of Worsening Seizures

Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures

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