Induction of Tumors by a Virus-Like Agent(s) Released by Tissue Culture

The Role of the Thymus in Polyoma Virus Infection<xref ref-type="fn" rid="fn1">2</xref>

“…Sachs et al reported that a mutant virus showed attenuation in its tumor-inducing properties, as measured on the basis of the plaque-forming unit of the virus (22). A high susceptibility in AKR mice has also been noted by several investigators (23)(24)(25).…”

“…Experiments involving thymectomy (5) and thymus transplantation (6,7) demonstrated that the thymus gland somehow participates in the 1 Reoolved October 23,1961; revised May 29, 1962. I This work was supported In part by grants C-4476•C1A and CRTY•5016 from the National Cancer Institute, National Institutes of Health, Public Health Service.…”

Biochemistry of Cancer

“…It has been termed "poly oma" virus because of the multiplicity of tumor types produced by what is apparently a single agent [Furth (1); (105)]. The agent has also been found to induce tumors in hamsters (107,108) and in rats (109); the tumors produced, however, differed for the various species. The agent has also been found to induce tumors in hamsters (107,108) and in rats (109); the tumors produced, however, differed for the various species.…”

Relationship of Viruses to Malignant Disease

“…Barriers play in viral oncogenesis. 6,14,15 Duran-Reynals demonstrated the relationship be¬ tween age of the host and the nature of response to the Rous sarcoma virus. 11 The same was observed with other agents.…”

“…17 They also showed that the chicken leukosis virus may infect some hosts and be transmitted from one host to another without the ap¬ pearance of tumors. 15,19,20 The Shope fibroma virus and the squirrel fibroma virus may be spread by contact and also probably by insect vectors. This phe-nomenon has been observed repeatedly with mammalian tumor viruses.…”