Inductive biomaterials for bone regeneration

Kasir, Rafid; Vernekar, Varadraj N.; Laurencin, Cato T.

doi:10.1557/jmr.2017.39

Cited by 19 publications

(16 citation statements)

References 119 publications

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“…HA is considered to be the gold standard in bone tissue regeneration. In clinical practice, it is used in the form of powders or granules as filler for bone replacement or for repair of post-resection defects [4,5]. HA is also successfully used as a coating material for metallic implants due to its bioactivity and favourable effects on the osseointegration process [6].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Hydroxyapatite materials, due to their high biocompatibility, play a crucial role in orthopaedics and bone surgery as alternatives to autologous bone grafts. It was also found that coatings of metallic implants with hydroxyapatite layer improve significantly their osseointegration. Due to its bioactivity, osteoconductivity and non-toxicity, hydroxyapatite is also widely used as a component of hybrid biomaterials. The implantation of "foreign" materials brings one major concern that is the risk of potential bone tissue infections or chronic osteomyelitis. In turn, the main problem concerning bacterial infection treatment is to obtain an adequate, bactericidal drug concentration maintained for a sufficient period of time in the bone tissue. Therefore, recent developments of materials engineering are focused on delivery antibiotics directly into the affected bone. To achieve this goal, hydroxyapatite-based materials are frequently studied as carriers for antibacterial drugs. For effective support of antibiotic therapy, the antibacterial activity of certain ions (including silver, zinc or copper) may be applied. In our work, we present recent developments on ceramic materials for bacterial bone infections: hydroxyapatite-based carriers for antibiotics and modifications of hydroxyapatite with antibacterial ions. In this review, state-of-the-art and current applications of such materials are presented and discussed. We want to also present our recent results.

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Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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“…The bone graft should exhibit no cytotoxicity whatsoever; furthermore, it should be biocompatible, osteo‐conductive, and osteo‐inductive 1 . In order to allow the osteo‐conductive and osteo‐inductive processes to take place, the bone graft should be porous 2‐4 . It is generally believed that the pores should be interconnected to each other, in order to allow the cells to colonize and proliferate inside pores 5‐9 …”

Section: Introductionmentioning

confidence: 99%

“…A previous in vitro study 10 suggested that the opening between pores should be larger than 20 µm in order for cell to migrate; nevertheless, its corresponding in vivo (rabbit femur) investigation indicated that the opening between pores should be at least 50 µm. Many studies claimed that without interconnected opening, the formation of new bone and blood vessels is not possible 2‐4,9,11 . The synthetic bone grafts with interconnected pore channels have therefore been developed 2‐4,12 .…”

Section: Introductionmentioning

confidence: 99%

“…Many studies claimed that without interconnected opening, the formation of new bone and blood vessels is not possible 2‐4,9,11 . The synthetic bone grafts with interconnected pore channels have therefore been developed 2‐4,12 . Various amounts of pores are introduced into these bone grafts through the use of fugitive polymer balls, 13 freeze casting, 14 gel‐foaming, 15,16 or robocasting 17 techniques.…”

Section: Introductionmentioning

confidence: 99%

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Attachment and migration of cells on porous bone graft

et al. 2020

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Porous bone graft is prepared using a gel‐foaming and sintering technique. The porosity of the bone graft is 70 vol%; the size of pores is around 130 µm. The pores are interconnected through opening of around 40 µm. The interactions between preosteoblast cells and the bone graft are then investigated. Although the pores are interconnected, most the cells are attached to the surface of bone graft. Only a few cells migrate into the cross‐section within a time span of 28 days. Such observation provides key information on pore structure design of bone graft.

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“…HA is currently considered to be the gold standard in bone tissue regeneration. It has been used in the form of powders or granules as filler, porous structure as scaffold for bone replacement, and repair of post-resection defects in clinical practice [6,7]. Due to its bioactivity, HA was also used as a coating material for metallic implants to enhance osseointegration process [8].…”

Section: Introductionmentioning

confidence: 99%

A functional apatite with antibacterial efficacy for bone tissue infections

Lim

Tong

Ho³

et al. 2019

J. Phys. Mater.

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Silver, silicon co-substituted hydroxyapatite (Ag, Si-HA) was developed to provide bone repair coupled with antibacterial effect, with the aim to address the problems arise in the treatment of bone tissue infections. In this study, Ag, Si-HA demonstrated substantially reduced attachment of Staphylococcus aureus, Propionibacterium acnes, Escherichia coli, and Pseudomonas aeruginosa as compared to HA at 12 h. Being a prolific opportunistic pathogen in bone tissue infections, we investigated if P. aeruginosa could develop resistance against Ag, Si-HA. Our study showed that despite repeated exposure to fresh population of P. aeruginosa every 48 h, Ag, Si-HA exhibited effective antibacterial properties against the growth of P. aeruginosa over 168 h, indicating low risk of inducing bacterial resistance against Ag, Si-HA. As P. aeruginosa produces exotoxins and harbours endotoxins on its cell call, together these toxins could delay healing process. We therefore examined if the effect of these toxins released by P. aeruginosa during the antibacterial assessment on the attachment of mesenchymal stem cells on HA and Ag, Si-HA. Unlike HA, cell attachment on Ag, Si-HA was not affected by the addition of supernatant obtained from the antibacterial assessment of HA and Ag, Si-HA. This demonstrated that Ag, Si-HA could inhibit the growth of bacteria as well as minimise or prevent the detrimental effect from bacteria toxins.

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Inductive biomaterials for bone regeneration

Cited by 19 publications

References 119 publications

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Attachment and migration of cells on porous bone graft

A functional apatite with antibacterial efficacy for bone tissue infections

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