With the rapid development of the national economy, the supporting role of molds to the national industry is becoming more and more indispensable. The purpose of this paper is to study the control and application of mechanical motion in stamping die design based on computer analysis. According to the principle of stamping die, the related mechanical motion of the die in the stamping process and its definition method are sorted out, which lays a foundation for the mechanical motion control. The interference detection algorithm based on die stamping motion simulation is established, and the method of automatically acquiring CATIA digital-analog information is studied, which not only standardizes the die design process, but also provides a basis for the realization of simulation motion control. each movement model. The static interference detection method adopted by the system is determined, and the method of distinguishing normal interference and abnormal interference is analyzed. Combining the CATIA interference detection with the motion law and motion curve of the process parts, the analysis of the mechanical motion control system is completed, which is of great significance to improve the production efficiency of the stamping line and speed up the processing speed of the stamping parts.