Inductively Coupled Plasma Cavity Ringdown Spectrometry

Miller, George P.; Winstead, Chris

doi:10.1039/a701523b

Cited by 28 publications

(50 citation statements)

References 29 publications

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“…The formaldehyde results we obtained in the UV region for (like many other CRDS measurements the PI has made) [20][21][22][23][24][25][26][27][28] were very close to the theoretical limits.…”

Section: Discussionsupporting

confidence: 78%

“…However, for CRDS, as equation 2 demonstrates, the ringdown time will incorporate absorption due to the concentration of both SO 2 and mercury. The PI and associates noted [20][21][22][23][24][25][26] in related research, that the presence of isotopic structure during a scan of the mercury 253 nm line raised the possibility (later, confirmed) that absorbance components of complex mixtures can be separated (Fig 4a). 27,28 For example, using a gas mixture containing 1.2 ppb mercury and 2175 ppm SO 2 respectively (Fig.…”

Section: Interferencesmentioning

confidence: 94%

“…The PI and associates noted [20][21][22][23][24][25][26] in related research, that the presence of isotopic structure during a scan of the mercury 253 nm line raised the possibility (later, confirmed) that absorbance components of complex mixtures can be separated (Fig 4a). 27,28 For example, using a gas mixture containing 1.2 ppb mercury and 2175 ppm SO 2 respectively ( By utilizing the fine absorption structure it has been demonstrated that accurate determination of individual components, down into the ppt range, can be successfully achieved.…”

Section: Interferencesmentioning

confidence: 94%

“…Simply put, this means that a CRDS instrument has the 7 potential to improve sensitivity by a factor of up to 10,000 over commercially available absorption-based instruments. During early research by the PI's group, [20][21][22][23][24][25][26] However, in this proposal it is molecular CRDS that is of interest. At the time of writing the original proposal, as far as the authors were aware, CRDS had never been used for breath analysis.…”

Section: Pmt Cavity Mirror Samplementioning

confidence: 99%

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An Exploratory Study of Cavity Ringdown Spectroscopy as a Noninvasive Breath Diagnostic for Breast Cancer

Miller¹

2006

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY)01/03/06 (From -To) REPORT TYPE Final DATES COVERED SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTEvery woman over 50 is recommended to have mammograms to monitor for breast cancer. The goal is to detect breast cancer as early as possible. The problems with the technique are well known and range from the exposure to X-rays to the difficulty of analysis, to patient resistance. Normal human breath contains a complex mixture of volatile organic compounds (VOCs). A number of these VOCs have been identified as candidate markers of various cancers (e.g. formaldehyde in breast cancer). Although breath analysis has been shown to have great potential as a diagnostic tool, most of the compounds of interest are exhaled in picomolar concentrations. Real-time breath analysis for these compounds is not possible with existing technology. Cavity ringdown spectroscopy (CRDS) is a measurement of the rate of absorption of a sample within a closed optical cavity, rather than the standard measurement of the absorbed signal strength over a given sample path. It maintains much of the simplicity of classical absorption spectroscopy, but has been demonstrated to provide an increase in sensitivity of up to 10,000 times. The objective is to evaluate the potential of CRDS to provide real-time formaldehyde concentrations in exhaled breath for the purpose of the detection of breast cancer. SUBJECT TERMSNone provided. Introduction:Normal human breath contains a complex mixture of several hundred volatile organic compounds (VOCs). A number of these compounds have been identified as candidate markers of various cancers (e.g. formaldehyde in breast cancer). Although breath analysis has been shown to have great potential as a diagnostic tool, most of the compounds of interest are exhaled in picomolar concentrations and may also be highly reactive and volatile. Real-time breath analysis for these compounds is not possible with existing technology. Cavity ringdown spectroscopy (CRDS) is a measurement of the rate of a...

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Section: Discussionsupporting

confidence: 78%

Section: Interferencesmentioning

confidence: 94%

Section: Interferencesmentioning

confidence: 94%

Section: Pmt Cavity Mirror Samplementioning

confidence: 99%

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An Exploratory Study of Cavity Ringdown Spectroscopy as a Noninvasive Breath Diagnostic for Breast Cancer

Miller¹

2006

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“…[2][3][4][5][6][7][8] In CRDS, the photon lifetime in an optical cavity is measured to extract the total intracavity loss ͑per pass͒ as a function of the photon frequency. When an absorbing species is present, absolute absorption intensities can be inferred by means of subtracting the baseline ͑nonreso-nant͒ losses of the cavity, which are determined while the laser is off resonance with atomic or molecular transitions.…”

Section: Introductionmentioning

confidence: 99%

Ringdown spectral photography

Scherer¹

1998

Chemical Physics Letters

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A new technique that enables frequency-resolved cavity ringdown absorption spectra to be obtained over a large optical bandwidth by a single laser shot is described. The technique, ringdown spectral photography ͑RSP͒, simultaneously employs two key principles to record the time and frequency response of an optical cavity along orthogonal axes of a CCD array detector. Previously, the principles employed in RSP were demonstrated with narrow-band laser light that was scanned in frequency ͓Chem. Phys. Lett. 292, 143 ͑1998͔͒. Here, the RSP method is demonstrated using single pulses of broadband visible laser light. The ability to obtain broad as well as rotationally resolved spectra over a large bandwidth with high sensitivity is demonstrated.

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Infrared Cavity Ringdown Spectroscopy

Wagner

Miller

Winstead

2001

Handbook of Vibrational Spectroscopy

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Coherent two‐dimensional vibrational spectroscopies use multiple laser excitations at high intensities where nonlinear processes dominate. These new spectroscopies can potentially probe molecular structure and dynamics in complex systems like multidimensional nuclear magnetic resonance (NMR) methods. We describe the development of the optical analogue to two‐dimensional NMR and its unique capabilities for achieving spectral selectivity. The approach uses four‐wave mixing where three lasers are focused onto a sample and new beams are generated by nonlinear processes. Their intensity depends on whether there are vibrational resonances with the three lasers. We have named these methods doubly vibrationally enhanced four wave mixing (DOVE‐FWM). These methods are related to infrared and Raman spectroscopy, but they are capable of dissecting vibrational spectra into the components that they are made of. These methods offer the potential of a powerful new probe of intra‐ and intermolecular interactions, molecular structure, and molecular dynamics.

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Inductively Coupled Plasma Cavity Ringdown Spectrometry

Cited by 28 publications

References 29 publications

An Exploratory Study of Cavity Ringdown Spectroscopy as a Noninvasive Breath Diagnostic for Breast Cancer

An Exploratory Study of Cavity Ringdown Spectroscopy as a Noninvasive Breath Diagnostic for Breast Cancer

Ringdown spectral photography

Infrared Cavity Ringdown Spectroscopy

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