Inductively Coupled Plasma Spectrometry

Broekaert, J. A. C.

doi:10.1002/9783527654703.ch16

Cited by 4 publications

(5 citation statements)

References 158 publications

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“…By comparison, typical LODs reported for ICP-MS measurements of 5 nm gold nanoparticles in nanopure water are on the order of 2.4 ppb (6.4 ppb when measured in nitric acid) or 12.2 nM of Au . Much higher values are more frequently reported, such as in a solution containing a high charge of organic molecules and interfering ions. − Therefore, the PET procedure developed in this study allows a detection sensitivity for AuNPs that is at least 10×, if not 100× more efficient. Finally, the sensitivity of PET can be further enhanced by increasing the Au: 89 Zr (IV) ratio or by integrating the signal over long time frames (e.g., 1-h time windows).…”

Section: Resultsmentioning

confidence: 82%

High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography

et al. 2021

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Ultrasmall nanoparticles (US-NPs; <20 nm in hydrodynamic size) are now included in a variety of pharmacological and cosmetic products, and new technologies are needed to detect at high sensitivity the passage of small doses of these products across biological barriers such as the skin. In this work, a diffusion cell adapted to positron emission tomography (PET), a highly sensitive imaging technology, was developed to measure the passage of gold NPs (AuNPs) in skin samples in continuous mode. US-AuNPs (3.2 nm diam.; TEM) were functionalized with deferoxamine (DFO) and radiolabeled with 89Zr(IV) (half-life: 3.3 days, matching the timeline of diffusion tests). The physicochemical properties of the functionalized US-AuNPs (US-AuNPs-PEG-DFO) were characterized by FTIR (DFO grafting; hydroxamate peaks: 1629.0 cm–1, 1569.0 cm–1), XPS (presence of the OC–N C 1s peak of DFO at 287.49 eV), and TGA (organic mass fraction). The passage of US-AuNPs-PEG-DFO-89Zr(IV) in skin samples was measured by PET, and the diffusion parameters were extracted thereby. The signals of radioactive US-AuNPs-PEG-DFO-89Zr(IV) leaving the donor compartment, passing through the skin, and entering the acceptor compartment were detected in continuous at concentrations as low as 2.2 nM of Au. The high-sensitivity acquisitions performed in continuous allowed for the first time to extract the lag time to the start of permeation, the lag time to start of the steady state, the diffusion coefficients, and the influx data for AuNPs permeating into the skin. PET could represent a highly valuable tool for the development of nanoparticle-containing topical formulations of drugs and cosmetics.

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Section: Resultsmentioning

confidence: 82%

High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography

et al. 2021

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“…Good agreement was obtained with the recommended values for Fe, Mg, K, and Ca in both whole blood and serum; for Cu in serum, and for Zn the values were much closer in blood and serum. As can be observed, better results were obtained with ICP-MS than with ICP-OES (14)(15)(16)(17)(18).…”

Section: Analyses Of Certified Reference Materialsmentioning

confidence: 82%

“…This paper presents two methods of sample preparation for the determination of 14 chemical ele-very low and the sensitivity of the technique is moderate, and on the other, it is necessary to dilute the samples before analysis because of the consistency, nature, and the high viscosity of the vitreous humor (14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the two techniques are applicable to the determination of a large number of elements, which is most of the over 70 elements that can be determined by ICP-OES and ICP-MS. Inductively coupled plasma mass spectrometry has the advantage of achieving very low detection limits and so it is the technique of choice for trace elemental analysis. Likewise, if the application calls for multi-element analysis of samples in a complicated matrix or if a high sample throughput rate with moderate sensitivity is required, then ICP-OES might be the best choice (4,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Analyses Of Certified Reference Materialsmentioning

confidence: 99%

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Multi-element Analysis of Vitreous Humor Samples by ICP-MS and ICP-OES

Vázquez¹,

Ibarra²,

Sibón³

et al. 2017

At.Spectrosc.

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“…Las condiciones instrumentales de funcionamiento se enumeran en la Tabla 16. También en la Tabla 17 se muestran las líneas analíticas más sensibles y sin interferencias espectrales en la matriz de la muestra, que fueron utilizadas para el análisis de los elementos estudiados (Broekaert, 2014;Froes, 2015;Padmasubashini, 2016 Para Mo y Cd no se obtuvo concordancia con los valores certificados con ninguno de los métodos de preparación de muestras. Aunque estos elementos son ionizados por el plasma de Ar del 85% al 95%, presentaban niveles de concentración muy bajos que no pudieron ser detectados por ICP-MS con ninguno de los métodos de preparación de la muestra.…”

Section: Plasma De Acoplamiento Inductivo Con Espectrometría óPtica (unclassified

Análisis de elementos traza por ICP-MS en sangre, humor vítreo y agua: su aplicación en el diagnóstico de sumersión

Méndez¹

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Cartagena 2017"La vida no es un problema que tiene que ser resuelto, sino una realidad que debe ser experimentada." Soren Kierkegaard AgradecimientosEn primer lugar, mi agradecimiento a la profesora Mª Dolores Pérez Cárceles por dirigir y coordinar este trabajo. He tenido mucha suerte de poder aprender de tus conocimientos, de tu perseverancia y de tu paciencia infinita.A Isidro Ibarra, co-director de esta tesis por facilitarme las tareas y ayudarme a salvar los obstáculos que han aparecido. gracias por crear tan buen ambiente de trabajo y por hacerme fácil el día a día y a Lola por orientarme y ayudarme con los formatos y la impresión.Agradecer a mi madre y a mi familia su apoyo incondicional y su cariño. Gracias por animarme en los momentos difíciles.A Lucía y Ana por el estímulo y la fuerza que me habéis dado para hacer este trabajo y me dais siempre.A Andrés, gracias por tu generosidad y por apoyarme incondicionalmente en este proyecto y en todos.

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Inductively Coupled Plasma Spectrometry

Cited by 4 publications

References 158 publications

High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography

High-Sensitivity Permeation Analysis of Ultrasmall Nanoparticles Across the Skin by Positron Emission Tomography

Multi-element Analysis of Vitreous Humor Samples by ICP-MS and ICP-OES

Análisis de elementos traza por ICP-MS en sangre, humor vítreo y agua: su aplicación en el diagnóstico de sumersión

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