2024
DOI: 10.1111/jpi.12953
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Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey

Annalida Bedini,
Jean A. Boutin,
Céline Legros
et al.

Abstract: The search for melatonin receptor agonists formed the main part of melatonin medicinal chemistry programs for the last three decades. In this short review, we summarize the two main aspects of these programs: the development of all the necessary tools to characterize the newly synthesized ligands at the two melatonin receptors MT1 and MT2, and the medicinal chemist's approaches to find chemically diverse ligands at these receptors. Both strategies are described. It turns out that the main source of tools were … Show more

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